QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (41) Citing Articles via Google Scholar Google Scholar Articles by Barski, J. J. Articles by Meyer, M. Search for Related Content PubMed PubMed Citation Articles by Barski, J. J. Articles by Meyer, M.

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 15, 2003, 23(8):3469

Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination

Jaroslaw J. Barski^{1, 2}, Jana Hartmann³, Christine R. Rose³, Freek Hoebeek⁴, Karin Mörl¹, Michael Noll-Hussong³, Chris I. De Zeeuw⁴, Arthur Konnerth³, and Michael Meyer^{1, 2}

¹ Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany, ² Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom, ³ Institute of Physiology, Ludwig-Maximilians-University of Munich, D-80336 Munich, Germany, and ⁴ Department of Neuroscience, Erasmus University Rotterdam, 3000DR Rotterdam, The Netherlands

Long-term depression (LTD) of Purkinje cell-parallel fiber synaptic transmission is a critical determinant of normal cerebellar function. Impairment of LTD through, for example, disruption of the metabotropic glutamate receptor-IP₃-calcium signaling cascade in mutant mice results in severe deficits of both synaptic transmission and cerebellar motor control. Here, we demonstrate that selective genetic deletion of the calcium-binding protein calbindin D-28k (calbindin) from cerebellar Purkinje cells results in distinctly different cellular and behavioral alterations. These mutants display marked permanent deficits of motor coordination and sensory processing. This occurs in the absence of alterations in a form of LTD implicated in the control of behavior. Analysis of synaptically evoked calcium transients in spines and dendrites of Purkinje cells demonstrated an alteration of time course and amplitude of fast calcium transients after parallel or climbing fiber stimulation. By contrast, the delayed metabotropic glutamate receptor-mediated calcium transients were normal. Our results reveal a unique role of Purkinje cell calbindin in a specific form of motor control and suggest that rapid calcium buffering may directly control behaviorally relevant neuronal signal integration.

Key words: calbindin D-28k; conditional null mutant; Purkinje cell; motor coordination; long-term depression; synaptically evoked calcium transients

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/2383469-09$05.00/0

This article has been cited by other articles:

				J. C. McCann and B. N. Ames Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J, April 1, 2008; 22(4): 982 - 1001. [Abstract] [Full Text] [PDF]

				D. V. Sarkisov and S. S.-H. Wang Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor J. Neurosci., January 2, 2008; 28(1): 133 - 142. [Abstract] [Full Text] [PDF]

				D. Orduz and I. Llano Recurrent axon collaterals underlie facilitating synapses between cerebellar Purkinje cells PNAS, November 6, 2007; 104(45): 17831 - 17836. [Abstract] [Full Text] [PDF]

				M. McEvoy, G. Cao, P. M. Llopis, M. Kundel, K. Jones, C. Hofler, C. Shin, and D. G. Wells Cytoplasmic Polyadenylation Element Binding Protein 1-Mediated mRNA Translation in Purkinje Neurons Is Required for Cerebellar Long-Term Depression and Motor Coordination J. Neurosci., June 13, 2007; 27(24): 6400 - 6411. [Abstract] [Full Text] [PDF]

				L. Servais, R. Hourez, B. Bearzatto, D. Gall, S. N. Schiffmann, and G. Cheron Purkinje cell dysfunction and alteration of long-term synaptic plasticity in fetal alcohol syndrome PNAS, June 5, 2007; 104(23): 9858 - 9863. [Abstract] [Full Text] [PDF]

				H. Schmidt, S. Kunerth, C. Wilms, R. Strotmann, and J. Eilers Spino-dendritic cross-talk in rodent Purkinje neurons mediated by endogenous Ca2+-binding proteins J. Physiol., June 1, 2007; 581(2): 619 - 629. [Abstract] [Full Text] [PDF]

				H. Schmidt, B. Schwaller, and J. Eilers Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons PNAS, April 19, 2005; 102(16): 5850 - 5855. [Abstract] [Full Text] [PDF]

				T. Collin, M. Chat, M. G. Lucas, H. Moreno, P. Racay, B. Schwaller, A. Marty, and I. Llano Developmental Changes in Parvalbumin Regulate Presynaptic Ca2+ Signaling J. Neurosci., January 5, 2005; 25(1): 96 - 107. [Abstract] [Full Text] [PDF]

				J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels Calcium Absorption Across Epithelia Physiol Rev, January 1, 2005; 85(1): 373 - 422. [Abstract] [Full Text] [PDF]

				C. I. Turnbull, K. Looi, J. E. Mangum, M. Meyer, R. J. Sayer, and M. J. Hubbard Calbindin Independence of Calcium Transport in Developing Teeth Contradicts the Calcium Ferry Dogma J. Biol. Chem., December 31, 2004; 279(53): 55850 - 55854. [Abstract] [Full Text] [PDF]

				J. Hartmann, R. Blum, Y. Kovalchuk, H. Adelsberger, R. Kuner, G. M. Durand, M. Miyata, M. Kano, S. Offermanns, and A. Konnerth Distinct Roles of G{alpha}q and G{alpha}11 for Purkinje Cell Signaling and Motor Behavior J. Neurosci., June 2, 2004; 24(22): 5119 - 5130. [Abstract] [Full Text] [PDF]

				G. Cheron, D. Gall, L. Servais, B. Dan, R. Maex, and S. N. Schiffmann Inactivation of Calcium-Binding Protein Genes Induces 160 Hz Oscillations in the Cerebellar Cortex of Alert Mice J. Neurosci., January 14, 2004; 24(2): 434 - 441. [Abstract] [Full Text] [PDF]

				R. Feil, J. Hartmann, C. Luo, W. Wolfsgruber, K. Schilling, S. Feil, J. J. Barski, M. Meyer, A. Konnerth, C. I. De Zeeuw, et al. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I J. Cell Biol., October 27, 2003; 163(2): 295 - 302. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help