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The Journal of Neuroscience, May 1, 2003, 23(9):3752

Distinct Developmental Modes and Lesion-Induced Reactions of Dendrites of Two Classes of Drosophila Sensory Neurons

Kaoru Sugimura^{1, 2}, Misato Yamamoto^{1, 3}, Ryusuke Niwa^{1, 5}, Daisuke Satoh^{1, 2}, Satoshi Goto⁴, Misako Taniguchi⁴, Shigeo Hayashi⁴, and Tadashi Uemura^{1, 5}

¹ Department of Molecular Genetics, The Institute for Virus Research, ² Graduate School of Science, and ³ Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan, ⁴ The Genetic Stock Research Center at the National Institute of Genetics for Drosophila Stocks, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan, and ⁵ Core Research for Evolutional Science and Technology, Japan Science and Technology, Kawaguchi 332-0012, Japan

Little has been understood about the underlying mechanisms that generate the morphological diversity of dendritic trees. Dendritic arborization neurons in Drosophila provide an excellent model system to tackle this question, and they are classified into classes I-IV in order of increasing arbor complexity. Here we have developed transgenic green fluorescent protein markers for class I or class IV cells, which allowed time-lapse recordings of dendritic birth in the embryo, its maturation processes in the larva, and lesion-induced reactions. The two classes used distinct strategies of dendritic emergence from the cell body and branching, which contributed to differences in their basic arbor patterns. In contrast to the class I cells examined, one cell of class IV, which was a focus in this study, continued to elaborate branches throughout larval stages, and it was much more capable of responding to the severing of branches. We also investigated the cellular basis of field formation between adjacent class IV cells. Our results support the fact that class-specific inhibitory interaction is necessary and sufficient for tiling and confirmed that this intercellular communication was at work at individual dendrodendritic interfaces. Finally, this inhibitory signaling appeared to play a central role when arbors of adjacent cells started meeting midway between the cells and until the body wall became partitioned into abutting, minimal-overlapping territories.

Key words: dendrites; Drosophila; time-lapse analysis; GAL4 enhancer trap; laser ablation; tiling

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2393752-09$05.00/0

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