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The Journal of Neuroscience, March 10, 2004, 24(10):2431-2439; doi:10.1523/JNEUROSCI.1598-03.2004
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Behavioral/Systems/Cognitive
The Role of the Dorsal Hippocampus in the Acquisition and Retrieval of Context Memory Representations
Patricia Matus-Amat, Emily A. Higgins, Ruth M. Barrientos, andJerry W. Rudy Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309
It is argued that the hippocampus contributes to contextual fear conditioning by supporting the acquisition of a conjunctive memory representation of context, which associates with shock. This function was examined by studying the context pre-exposure facilitation effect (CPFE). A rat that is shocked immediately after being placed into a context subsequently displays almost no fear of that context. However, if it is pre-exposed to the context the day before immediate shock, it displays significant freezing to that context. By using 5-aminomethyl-3-hydroxysoxazole to temporarily inactivate the dorsal hippocampus (DH) at three different phases of the procedure, which produces the CPFE, we show that the hippocampus is necessary for the following: (1) acquisition of the context memory, (2) retrieval of this memory at the time of immediate shock, and (3) retrieval of the context-shock memory at the time of testing. In contrast, inactivating the DH before a standard contextual shock experience had no effect on contextual fear conditioning. These results support the view that two processes can support contextual fear conditioning: (1) conditioning to the conjunctive representation, which depends on the hippocampus, and (2) conditioning to the features that make up the context, which does not.
Key words: hippocampus; contextual fear conditioning; context pre-exposure facilitation effect; conjunctive representation; pattern completion; declarative memory
Received July 2, 2003; revised January 8, 2004; accepted January 8, 2004.
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