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The Journal of Neuroscience, March 24, 2004, 24(12):2934-2941; doi:10.1523/JNEUROSCI.5505-03.2004

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Behavioral/Systems/Cognitive
Temporal Properties of Cerebellar-Dependent Memory Consolidation

Samuel F. Cooke,¹ Phillip J. E. Attwell,² and Christopher H. Yeo²

¹Division of Neurophysiology, The National Institute for Medical Research, London NW7 1AA, United Kingdom, and ²Department Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom

Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible inactivations of the cerebellar cortex, but not of the cerebellar nuclei, with the GABA_A receptor agonist muscimol. Here, the temporal properties of this cerebellar cortex-dependent consolidation were examined using delayed infusions of muscimol in cortical lobule HVI. Cortical infusions delayed by 5 or 45 min after a conditioning session produced significant and very similar impairments of consolidation, but infusions delayed by 90 min produced little or no impairment. Behavioral measures indicate that the muscimol infusions produced significant effects after 30 min and they lasted for a few hours. So, over a time window beginning 1 hr after the end of the training session and closing 1 hr after that, intracortical activity is critical for consolidation of this motor memory.

Key words: motor learning; consolidation; classical conditioning; nictitating membrane; muscimol; olivo-cortico-nuclear loop; time window

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Received Dec 15, 2003; revised December 15, 2003; accepted February 12, 2004.

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