WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Discover www.zeiss.de/sensitivity
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, March 24, 2004, 24(12):3023-3030; doi:10.1523/JNEUROSCI.5745-03.2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murphy, G. J.
Right arrow Articles by Isaacson, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, G. J.
Right arrow Articles by Isaacson, J. S.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CALCIUM COMPOUNDS
*CALCIUM, ELEMENTAL
*GLUTAMIC ACID HYDROCHLORIDE

 Previous Article  |  Next Article 

Cellular/Molecular
Sensory Neuron Signaling to the Brain: Properties of Transmitter Release from Olfactory Nerve Terminals

Gabe J. Murphy, Lindsey L. Glickfeld, Zev Balsen, and Jeffry S. Isaacson

Neuroscience Graduate Program and Department of Neuroscience, University of California, San Diego School of Medicine, La Jolla, California 92093-0608

Olfactory receptor neurons (ORNs) convey sensory information directly to the CNS via conventional glutamatergic synaptic contacts in olfactory bulb glomeruli. To better understand the process by which information contained in the odorant-evoked firing of ORNs is transmitted to the brain, we examined the properties of glutamate release from olfactory nerve (ON) terminals in slices of the rat olfactory bulb. We show that marked paired pulse depression is the same in simultaneously recorded periglomerular and tufted neurons, and that this form of short-term plasticity is attributable to a reduction of glutamate release from ON terminals. We used the progressive blockade of NMDA receptor (NMDAR) EPSCs by MK-801 [(5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-10-imine hydrogen maleate] and stationary fluctuation analysis of AMPA receptor (AMPAR) EPSCs to determine the probability of release (Pr) of ON terminals; both approaches indicated that Pr is unusually high (>=0.8). The low-affinity glutamate receptor antagonists {gamma}-D-glutamylglycine and L-amino-5-phosphonovaleric acid blocked ON-evoked AMPAR- and NMDAR-mediated EPSCs, respectively, to the same extent under conditions of low and high Pr, suggesting that multivesicular release is not a feature of ON terminals. Although release from most synapses exhibits a highly nonlinear dependence on extracellular Ca2+, we find that the relationship between glutamate release and extracellular Ca2+ at ON terminals is nearly linear. Our results suggest that ON terminals have specialized features that may contribute to the reliable transmission of sensory information from nose to brain.

Key words: MK-801; olfactory bulb; glutamate; release probability; paired pulse depression; calcium; multivesicular release

Received Dec 30, 2003; revised February 10, 2003; accepted February 10, 2003.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. S. Grubb, A. Nissant, K. Murray, and P.-M. Lledo
Functional Maturation of the First Synapse in Olfaction: Development and Adult Neurogenesis
J. Neurosci., March 12, 2008; 28(11): 2919 - 2932.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. J. Maher and G. L. Westbrook
Co-Transmission of Dopamine and GABA in Periglomerular Cells
J Neurophysiol, March 1, 2008; 99(3): 1559 - 1564.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. C. Nawroth, C. A. Greer, W. R. Chen, S. B. Laughlin, and G. M. Shepherd
An Energy Budget for the Olfactory Glomerulus
J. Neurosci., September 5, 2007; 27(36): 9790 - 9800.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. J. Tyler, G. C. Petzold, S. K. Pal, and V. N. Murthy
Experience-Dependent Modification of Primary Sensory Synapses in the Mammalian Olfactory Bulb
J. Neurosci., August 29, 2007; 27(35): 9427 - 9438.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. De Saint Jan and G. L. Westbrook
Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb
J. Neurosci., January 3, 2007; 27(1): 132 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. A. Biro, N. B. Holderith, and Z. Nusser
Release Probability-Dependent Scaling of the Postsynaptic Responses at Single Hippocampal GABAergic Synapses
J. Neurosci., November 29, 2006; 26(48): 12487 - 12496.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. W. Bailey, Y.-H. Jin, M. W. Doyle, S. M. Smith, and M. C. Andresen
Vasopressin inhibits glutamate release via two distinct modes in the brainstem.
J. Neurosci., June 7, 2006; 26(23): 6131 - 6142.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H.-C. Lu, D. A. Butts, P. S. Kaeser, W.-C. She, R. Janz, and M. C. Crair
Role of efficient neurotransmitter release in barrel map development.
J. Neurosci., March 8, 2006; 26(10): 2692 - 2703.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Vucinic, L. B. Cohen, and E. K. Kosmidis
Interglomerular Center-Surround Inhibition Shapes Odorant-Evoked Input to the Mouse Olfactory Bulb In Vivo
J Neurophysiol, March 1, 2006; 95(3): 1881 - 1887.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. M. Christie and C. E. Jahr
Multivesicular Release at Schaffer Collateral-CA1 Hippocampal Synapses
J. Neurosci., January 4, 2006; 26(1): 210 - 216.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Wachowiak, J. P. McGann, P. M. Heyward, Z. Shao, A. C. Puche, and M. T. Shipley
Inhibition of Olfactory Receptor Neuron Input to Olfactory Bulb Glomeruli Mediated by Suppression of Presynaptic Calcium Influx
J Neurophysiol, October 1, 2005; 94(4): 2700 - 2712.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Mutoh, Q. Yuan, and T. Knopfel
Long-Term Depression at Olfactory Nerve Synapses
J. Neurosci., April 27, 2005; 25(17): 4252 - 4259.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. De Saint Jan and G. L. Westbrook
Detecting Activity in Olfactory Bulb Glomeruli with Astrocyte Recording
J. Neurosci., March 16, 2005; 25(11): 2917 - 2924.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. L Johnson, W. Marcotti, and C. J Kros
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells
J. Physiol., February 15, 2005; 563(1): 177 - 191.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P.-M. Lledo, G. Gheusi, and J.-D. Vincent
Information Processing in the Mammalian Olfactory System
Physiol Rev, January 1, 2005; 85(1): 281 - 317.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-