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The Journal of Neuroscience, March 31, 2004, 24(13):3260-3267; doi:10.1523/JNEUROSCI.4702-03.2004

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Behavioral/Systems/Cognitive
Modification of Saccades Evoked by Stimulation of Frontal Eye Field during Invisible Target Tracking

Andrei Barborica and Vincent P. Ferrera

Department of Psychiatry, Center for Neurobiology and Behavior, Keck-Mahoney Center for Brain and Behavior Research, Columbia University, New York, New York 10032

We investigated the internal representation of invisible moving targets using electrical microstimulation in the prefrontal cortex. Monkeys were trained to make saccades to the extrapolated position of a small moving target that was rendered invisible during part of its trajectory. Although the target was invisible, involuntary saccades were evoked by electrical microstimulation of the frontal eye field. Stimulation was applied at different times relative to the disappearance of the target while the monkey fixated. When stimulation was applied immediately after target disappearance, electrically evoked saccades were biased toward the starting point of the target trajectory. When stimulation was applied later in the trial, evoked saccades were biased toward the end of the trajectory. The bias in evoked saccade direction changed continuously over time. The magnitude and statistical significance of the electrically evoked saccade deviation depended on the accuracy of the monkeys' voluntary saccades relative to the invisible target. The results suggest that covert tracking is accompanied by a continuously shifting saccade plan that moves along the target path.

Key words: monkey; frontal eye field; stimulation; prediction; saccade; planning

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Received July 30, 2003; revised February 22, 2004; accepted February 22, 2004.

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