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The Journal of Neuroscience, April 14, 2004, 24(15):3770-3776; doi:10.1523/JNEUROSCI.4775-03.2004

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Cellular/Molecular
Endoplasmic Reticulum Export Site Formation and Function in Dendrites

Meir Aridor,¹ Amy K. Guzik,² Anna Bielli,¹ and Kenneth N. Fish²

¹Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and ²The Harold L. Dorris Neurological Research Center and Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037

The elongated and polarized characteristics of neurons render targeting of receptors to the plasma membrane of distal axonal projections and dendritic branches a major sorting task. Although the majority of biosynthetic cargo synthesis, transport, and sorting are believed to occur in the soma, local membrane protein translation and sorting has been reported recently to take place in dendrites and axons. We investigated where endoplasmic reticulum (ER) export occurs in dendrites using an in vitro permeabilized neuron system that enables us to specifically control the assembly of ER export sites. We show that ER export sites are assembled regularly throughout the entire dendritic tree by the regulated sequential recruitment of Sar1 and COPII (coat protein complex II). Moreover, activation of metabotropic glutamate receptors leads to the recruitment of the NMDA receptor subunit NR1 to remodeled ER export sites. We propose that regulation of receptor assembly and export from the ER in dendrites plays an important role in modulating receptor surface expression and neuronal function.

Key words: Sar1; COP-coated vesicles; ER export; secretory pathway; dendrite; biological transport

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Received Oct 22, 2003; revised February 17, 2004; accepted February 19, 2004.

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