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The Journal of Neuroscience, January 14, 2004, 24(2):310-318; doi:10.1523/JNEUROSCI.4287-03.2004

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Development/Plasticity/Repair
Semaphorin3D Guides Retinal Axons along the Dorsoventral Axis of the Tectum

Yan Liu,¹ Jason Berndt,^1,2 Fengyun Su,³ Hiroshi Tawarayama,⁴ Wataru Shoji,⁴ John Y. Kuwada,³ and Mary C. Halloran^1,2

¹Departments of Zoology and Anatomy and ²Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, ³Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, 48109-1048, and ⁴Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980-8575, Japan

We examined the role of Sema3D, a semaphorin of previously unknown function, in guiding retinal ganglion cell (RGC) axons to the optic tectum in the developing zebrafish. Sema3D is expressed more strongly in the ventral versus dorsal tectum, suggesting that it may participate in guiding RGC axons along the dorsoventral axis of the tectum. Ubiquitous misexpression of Sema3D in transgenic zebrafish inhibits ventral but not dorsal RGC axon growth. In addition, ventral RGC axons avoid or stop at individual cells misexpressing Sema3D along their pathway. Sema3D ubiquitous misexpression at later stages also causes ventral RGC axon arbors to spread more widely along the dorsoventral axis of the tectum. Knock-down of Sema3D with morpholino antisense causes ventral RGC axons to extend aberrantly into the ventral tectum. These results suggest that Sema3D in the ventral tectum normally acts to inhibit ventral RGCs from extending into ventral tectum, ensuring their correct innervation of dorsal tectum.

Key words: semaphorin; neuropilin; retinal axon guidance; retinotectal; transgenic zebrafish; topographic map

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Received Sep 20, 2003; accepted October 13, 2003.

This article has been cited by other articles:

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				T. Xiao, T. Roeser, W. Staub, and H. Baier A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection Development, July 1, 2005; 132(13): 2955 - 2967. [Abstract] [Full Text] [PDF]

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