WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience MBF Stereo Investigator
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, July 14, 2004, 24(28):6248-6257; doi:10.1523/JNEUROSCI.0985-04.2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (35)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Knöll, B.
Right arrow Articles by Drescher, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Knöll, B.
Right arrow Articles by Drescher, U.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Src Family Kinases Are Involved in EphA Receptor-Mediated Retinal Axon Guidance

Bernd Knöll and Uwe Drescher

Medical Research Council Centre for Developmental Neurobiology, King's College London, London SE1 1UL, United Kingdom

EphA receptor tyrosine kinases and their ephrin ligands play important roles in wiring of the developing nervous system. We have investigated here the function of Src family kinases (SFKs) in the retinotectal projection to dissect the signaling pathways by which EphA receptors control actin/microtubule rearrangements that underlie growth cone guidance and collapse. Both EphAs and SFKs are expressed broadly in retinal growth cones, and SFKs are recruited to EphA receptors after ephrinA stimulation. In the stripe and growth cone collapse assays we observe an abolition of EphA-mediated repulsion after inhibiting SFKs, either pharmacologically or enzymatically via electroporation-mediated overexpression of the SFK inhibitor Csk. In addition, we identify cortactin and the RhoGEF ephexin, which interact with EphA receptors in retinal axons, as targets of SFK-dependent tyrosine phosphorylation. In sum, our data suggest an important role of SFKs as downstream signaling molecules in EphA receptor-mediated repulsive axon guidance.

Key words: retinotectal projection; axon guidance; Eph family; Src family kinase; intracellular signaling; actin cytoskeleton

Received March 17, 2004; revised May 25, 2004; accepted May 25, 2004.




This article has been cited by other articles:


Home page
 DevelopmentHome page
R. R. Wouda, M. R. K. S. Bansraj, A. W. M. de Jong, J. N. Noordermeer, and L. G. Fradkin
Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system
Development, July 1, 2008; 135(13): 2277 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
W. B. Fang, R. C. Ireton, G. Zhuang, T. Takahashi, A. Reynolds, and J. Chen
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism
J. Cell Sci., February 1, 2008; 121(3): 358 - 368.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Shin, C. Gu, E. Park, and S. Park
Identification of Phosphotyrosine Binding Domain-Containing Proteins as Novel Downstream Targets of the EphA8 Signaling Function
Mol. Cell. Biol., December 1, 2007; 27(23): 8113 - 8126.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
K. Fizazi
The role of Src in prostate cancer
Ann. Onc., November 1, 2007; 18(11): 1765 - 1773.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Zhang, T. Sawada, X. Jing, H. Yokote, X. Yan, and K. Sakaguchi
Regulation of Ephexin1, a Guanine Nucleotide Exchange Factor of Rho Family GTPases, by Fibroblast Growth Factor Receptor-mediated Tyrosine Phosphorylation
J. Biol. Chem., October 19, 2007; 282(42): 31103 - 31112.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Shi, W.-Y. Fu, K.-W. Hung, C. Porchetta, C. Hall, A. K. Y. Fu, and N. Y. Ip
{alpha}2-Chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse
PNAS, October 9, 2007; 104(41): 16347 - 16352.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
C. Bourgin, K. K. Murai, M. Richter, and E. B. Pasquale
The EphA4 receptor regulates dendritic spine remodeling by affecting {beta}1-integrin signaling pathways
J. Cell Biol., September 24, 2007; 178(7): 1295 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Parri, F. Buricchi, E. Giannoni, G. Grimaldi, T. Mello, G. Raugei, G. Ramponi, and P. Chiarugi
EphrinA1 Activates a Src/Focal Adhesion Kinase-mediated Motility Response Leading to Rho-dependent Actino/Myosin Contractility
J. Biol. Chem., July 6, 2007; 282(27): 19619 - 19628.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Zimmer, B. Kastner, F. Weth, and J. Bolz
Multiple Effects of Ephrin-A5 on Cortical Neurons Are Mediated by Src Family Kinases
J. Neurosci., May 23, 2007; 27(21): 5643 - 5653.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
I. R. Evans, T. Renne, F. B. Gertler, and C. D. Nobes
Ena/VASP proteins mediate repulsion from ephrin ligands
J. Cell Sci., January 15, 2007; 120(2): 289 - 298.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Dufour, J. Egea, K. Kullander, R. Klein, and P. Vanderhaeghen
Genetic analysis of EphA-dependent signaling mechanisms controlling topographic mapping in vivo
Development, November 15, 2006; 133(22): 4415 - 4420.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
L. I. Cosen-Binker and A. Kapus
Cortactin: The Gray Eminence of the Cytoskeleton.
Physiology, October 1, 2006; 21(5): 352 - 361.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. Pfaff, U. Fiedler, and H. G. Augustin
Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking
J. Leukoc. Biol., October 1, 2006; 80(4): 719 - 726.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Liu, T. Nakazawa, T. Tezuka, and T. Yamamoto
Physical and Functional Interaction of Fyn Tyrosine Kinase with a Brain-enriched Rho GTPase-activating Protein TCGAP
J. Biol. Chem., August 18, 2006; 281(33): 23611 - 23619.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Nicol, A. Muzerelle, J. P. Rio, C. Metin, and P. Gaspar
Requirement of Adenylate Cyclase 1 for the Ephrin-A5-Dependent Retraction of Exuberant Retinal Axons
J. Neurosci., January 18, 2006; 26(3): 862 - 872.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
W. Li, J. Aurandt, C. Jurgensen, Y. Rao, and K.-L. Guan
FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5
J. Cell Sci., January 1, 2006; 119(1): 47 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Arimura, C. Menager, Y. Kawano, T. Yoshimura, S. Kawabata, A. Hattori, Y. Fukata, M. Amano, Y. Goshima, M. Inagaki, et al.
Phosphorylation by Rho Kinase Regulates CRMP-2 Activity in Growth Cones
Mol. Cell. Biol., November 15, 2005; 25(22): 9973 - 9984.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Robles, S. Woo, and T. M. Gomez
Src-Dependent Tyrosine Phosphorylation at the Tips of Growth Cone Filopodia Promotes Extension
J. Neurosci., August 17, 2005; 25(33): 7669 - 7681.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Matsuoka, H. Obama, M. L. Kelly, T. Matsui, and M. Nakamoto
Biphasic Functions of the Kinase-defective Ephb6 Receptor in Cell Adhesion and Migration
J. Biol. Chem., August 12, 2005; 280(32): 29355 - 29363.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-