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The Journal of Neuroscience, August 4, 2004, 24(31):7015-7023; doi:10.1523/JNEUROSCI.5492-03.2004

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Behavioral/Systems/Cognitive
Putting Fear in Its Place: Remapping of Hippocampal Place Cells during Fear Conditioning

Marta A. P. Moita,¹ Svetlana Rosis,² Yu Zhou,² Joseph E. LeDoux,² and Hugh T. Blair³

¹Instituto Gulbenkian de Sciencia, P-2780-156 Oeiras, Portugal, ²Center for Neural Science, New York University, New York, New York 10003, and ³Psychology Department, University of California, Los Angeles, California 90095

We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment. Fear conditioning caused many place cells to alter (or remap) their preferred firing locations in the training environment, whereas most cells remained stable in the control environment. This finding indicates that aversive reinforcement can induce place cell remapping even when the environment itself remains unchanged. Furthermore, contextual fear conditioning caused significantly more remapping of place cells than auditory fear conditioning, suggesting that place cell remapping was related to the rat's learned fear of the environment. These results suggest that one possible function of place cell remapping may be to generate new spatial representations of a single environment, which could help the animal to discriminate among different motivational contexts within that environment.

Key words: activity; aversion; CA1; conditioned (conditioning); extracellular; hippocampus; learning

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Received Dec 13, 2003; revised May 28, 2004; accepted June 3, 2004.

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