WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience New in Neuroscience from Oxford
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, August 18, 2004, 24(33):7366-7377; doi:10.1523/JNEUROSCI.1739-04.2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (57)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schratt, G. M.
Right arrow Articles by Greenberg, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schratt, G. M.
Right arrow Articles by Greenberg, M. E.

 Previous Article  |  Next Article 

Cellular/Molecular
BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development

Gerhard M. Schratt,1 * Elizabeth A. Nigh,2 * Wen G. Chen,3 Linda Hu,1 and Michael E. Greenberg1

1Departments of Neurology and Neurobiology, 2Program in Neuroscience, and 3Program in Biological and Biomedical Sciences, Harvard Medical School and Division of Neuroscience, Children's Hospital, Boston, Massachusetts 02115

Local regulation of mRNA translation plays an important role in axon guidance, synaptic development, and neuronal plasticity. Little is known, however, regarding the mechanisms that control translation in neurons, and only a few mRNAs have been identified that are locally translated within axon and dendrites. Using Affymetrix gene arrays to identify mRNAs that are newly associated with polysomes after exposure to BDNF, we identified subsets of mRNAs for which translation is enhanced in neurons at different developmental stages. In mature neurons, many of these mRNAs encode proteins that are known to function at synapses, including CamKII{alpha}, NMDA receptor subunits, and the postsynaptic density (PSD) scaffolding protein Homer2. BDNF regulates the translation of Homer2 locally in the synaptodendritic compartment by activating translational initiation via a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway. These findings suggest that BDNF likely regulates synaptic function by inducing the local synthesis of numerous synaptic proteins. The local translation of the cytoskeleton-associated protein Homer2 in particular might have important implications for growth cone dynamics and dendritic spine development.

Key words: BDNF; translation; microarray; axon guidance; synaptic plasticity; rapamycin

Received May 6, 2004; revised July 7, 2004; accepted July 8, 2004.




This article has been cited by other articles:


Home page
 J. Nutr.Home page
P. V. Tran, E. S. Carlson, S. J. B. Fretham, and M. K. Georgieff
Early-Life Iron Deficiency Anemia Alters Neurotrophic Factor Expression and Hippocampal Neuron Differentiation in Male Rats
J. Nutr., December 1, 2008; 138(12): 2495 - 2501.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
P. Bekinschtein, M. Cammarota, I. Izquierdo, and J. H. Medina
Reviews: BDNF and Memory Formation and Storage
Neuroscientist, April 1, 2008; 14(2): 147 - 156.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
M. Niculescu, S. A. Perrine, J. S. Miller, M. E. Ehrlich, and E. M. Unterwald
Trk: A Neuromodulator of Age-Specific Behavioral and Neurochemical Responses to Cocaine in Mice
J. Neurosci., January 30, 2008; 28(5): 1198 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Hou, D. Zhang, L. Jarzylo, R. L. Huganir, and H.-Y. Man
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
PNAS, January 15, 2008; 105(2): 775 - 780.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Hayashi, T. Kasahara, K. Iwamoto, M. Ishiwata, M. Kametani, C. Kakiuchi, T. Furuichi, and T. Kato
The Role of Brain-derived Neurotrophic Factor (BDNF)-induced XBP1 Splicing during Brain Development
J. Biol. Chem., November 23, 2007; 282(47): 34525 - 34534.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
S. Pan, M. Shi, J. Jin, R. L. Albin, A. Lieberman, M. Gearing, B. Lin, C. Pan, X. Yan, D. T. Kashima, et al.
Proteomics Identification of Proteins in Human Cortex Using Multidimensional Separations and MALDI Tandem Mass Spectrometer
Mol. Cell. Proteomics, October 1, 2007; 6(10): 1818 - 1823.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Messaoudi, T. Kanhema, J. Soule, A. Tiron, G. Dagyte, B. da Silva, and C. R. Bramham
Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate Gyrus In Vivo
J. Neurosci., September 26, 2007; 27(39): 10445 - 10455.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. S. Weragoda and E. T. Walters
Serotonin Induces Memory-Like, Rapamycin-Sensitive Hyperexcitability in Sensory Axons of Aplysia That Contributes to Injury Responses
J Neurophysiol, September 1, 2007; 98(3): 1231 - 1239.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. E. Levin
Neurotrophism and energy homeostasis: perfect together
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R988 - R991.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Tsokas, T. Ma, R. Iyengar, E. M. Landau, and R. D. Blitzer
Mitogen-Activated Protein Kinase Upregulates the Dendritic Translation Machinery in Long-Term Potentiation by Controlling the Mammalian Target of Rapamycin Pathway
J. Neurosci., May 30, 2007; 27(22): 5885 - 5894.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Caldeira, C. V. Melo, D. B. Pereira, R. Carvalho, S. S. Correia, D. S. Backos, A. L. Carvalho, J. A. Esteban, and C. B. Duarte
Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery of{alpha}-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons
J. Biol. Chem., April 27, 2007; 282(17): 12619 - 12628.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Burkhalter, H. Fiumelli, J. D. Erickson, and J.-L. Martin
A Critical Role for System A Amino Acid Transport in the Regulation of Dendritic Development by Brain-derived Neurotrophic Factor (BDNF)
J. Biol. Chem., February 23, 2007; 282(8): 5152 - 5159.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Huang, B. N. Kang, J. Tian, Y. Liu, H. R. Luo, L. Hester, and S. H. Snyder
The Cationic Amino Acid Transporters CAT1 and CAT3 Mediate NMDA Receptor Activation-Dependent Changes in Elaboration of Neuronal Processes via the Mammalian Target of Rapamycin mTOR Pathway
J. Neurosci., January 17, 2007; 27(3): 449 - 458.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. G. Parsons, G. M. Gafford, and F. J. Helmstetter
Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term Fear Memory in Amygdala Neurons
J. Neurosci., December 13, 2006; 26(50): 12977 - 12983.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. F. Raab-Graham, P. C. G. Haddick, Y. N. Jan, and L. Y. Jan
Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
Science, October 6, 2006; 314(5796): 144 - 148.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Martin-Pena, A. Acebes, J.-R. Rodriguez, A. Sorribes, G. G. de Polavieja, P. Fernandez-Funez, and A. Ferrus
Age-Independent Synaptogenesis by Phosphoinositide 3 Kinase
J. Neurosci., October 4, 2006; 26(40): 10199 - 10208.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Gong, C. S. Park, N. R. Abbassi, and S.-J. Tang
Roles of Glutamate Receptors and the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Activity-dependent Dendritic Protein Synthesis in Hippocampal Neurons
J. Biol. Chem., July 7, 2006; 281(27): 18802 - 18815.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. C. Martin and R. S. Zukin
RNA trafficking and local protein synthesis in dendrites: an overview.
J. Neurosci., July 5, 2006; 26(27): 7131 - 7134.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. M. Schuman, J. L. Dynes, and O. Steward
Synaptic regulation of translation of dendritic mRNAs.
J. Neurosci., July 5, 2006; 26(27): 7143 - 7146.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. W. Grossman, G. M. Aldridge, I. J. Weiler, and W. T. Greenough
Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
J. Neurosci., July 5, 2006; 26(27): 7151 - 7155.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Takaki, S. Nakayama, H. Misawa, T. Nakagawa, and H. Kuniyasu
In Vitro Formation of Enteric Neural Network Structure in a Gut-Like Organ Differentiated from Mouse Embryonic Stem Cells
Stem Cells, June 1, 2006; 24(6): 1414 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Cota, K. Proulx, K. A. B. Smith, S. C. Kozma, G. Thomas, S. C. Woods, and R. J. Seeley
Hypothalamic mTOR signaling regulates food intake.
Science, May 12, 2006; 312(5775): 927 - 930.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-Y. Hu, F. Wu, and S. Schacher
Two Signaling Pathways Regulate the Expression and Secretion of a Neuropeptide Required for Long-Term Facilitation in Aplysia
J. Neurosci., January 18, 2006; 26(3): 1026 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
G. STEFANI and F. SLACK
MicroRNAs in Search of a Target
Cold Spring Harb Symp Quant Biol, January 1, 2006; 71(0): 129 - 134.
[Abstract] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-