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The Journal of Neuroscience, September 22, 2004, 24(38):8379-8382; doi:10.1523/JNEUROSCI.2040-04.2004
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BRIEF COMMUNICATION
Low Ethanol Concentrations Selectively Augment the Tonic Inhibition Mediated bySubunit-Containing GABAA Receptors in Hippocampal Neurons
Weizheng Wei,1 Leonardo Coutinho Faria,1,2 andIstvan Mody1 1Departments of Neurology and Physiology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, and 2Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo–Escola Paulista de Medicina, São Paulo, 04023-900 Brazil
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by
subunit-containing GABAA receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by
5 subunit-containing receptors of CA1 pyramidal cells is not affected. The effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the
Key words: alcohol; CA1; dentate; GABA; hippocampus; inhibition
Received May 26, 2004; revised July 15, 2004; accepted August 12, 2004.
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