QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 28, 2004, 24(4):773-780; doi:10.1523/JNEUROSCI.0949-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (59) Citing Articles via Google Scholar Google Scholar Articles by Christakou, A. Articles by Everitt, B. J. Search for Related Content PubMed PubMed Citation Articles by Christakou, A. Articles by Everitt, B. J.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Prefrontal Cortical–Ventral Striatal Interactions Involved in Affective Modulation of Attentional Performance: Implications for Corticostriatal Circuit Function

Anastasia Christakou, Trevor W. Robbins, and Barry J. Everitt

Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom

Anatomically segregated systems linking the frontal cortex and the striatum are involved in various aspects of cognitive, affective, and motor processing. In this study, we examined the effects of combined unilateral lesions of the medial prefrontal cortex (mPFC) and the core subregion of the nucleus accumbens (AcbC) in opposite hemispheres (disconnection) on a continuous performance, visual attention test [five-choice serial reaction-time task (5CSRTT)]. The disconnection lesion produced a set of specific changes in performance of the 5CSRTT, resembling changes that followed bilateral AcbC lesions while, in addition, comprising a subset of the behavioral changes after bilateral mPFC lesions previously reported using the same task. Specifically, both mPFC/AcbC disconnection and bilateral AcbC lesions markedly affected aspects of response control related to affective feedback, as indexed by perseverative responding in the 5CSRTT. These effects were comparable, although not identical, to those in animals with either bilateral AcbC or mPFC/AcbC disconnection lesions. The mPFC/AcbC disconnection resulted in a behavioral profile largely distinct from that produced by disconnection of a similar circuit described previously, between the mPFC and the dorsomedial striatum, which were shown to form a functional network underlying aspects of visual attention and attention to action. This distinction provides an insight into the functional specialization of corticostriatal circuits in similar behavioral contexts.

Key words: corticostriatal circuits; visual–spatial attention; affective modulation; action control; medial prefrontal cortex; nucleus accumbens core

---

Received April 1, 2003; revised October 31, 2003; accepted October 31, 2003.

This article has been cited by other articles:

				W. Hauber and S. Sommer Prefrontostriatal Circuitry Regulates Effort-Related Decision Making Cereb Cortex, October 1, 2009; 19(10): 2240 - 2247. [Abstract] [Full Text] [PDF]

				A. J. Gruber, E. M. Powell, and P. O'Donnell Cortically Activated Interneurons Shape Spatial Aspects of Cortico-Accumbens Processing J Neurophysiol, April 1, 2009; 101(4): 1876 - 1882. [Abstract] [Full Text] [PDF]

				S. Mingote, L. Font, A. M. Farrar, R. Vontell, L. T. Worden, C. M. Stopper, R. G. Port, K. S. Sink, J. G. Bunce, J. J. Chrobak, et al. Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway J. Neurosci., September 3, 2008; 28(36): 9037 - 9046. [Abstract] [Full Text] [PDF]

				V. B. McGinty and A. A. Grace Selective Activation of Medial Prefrontal-to-Accumbens Projection Neurons by Amygdala Stimulation and Pavlovian Conditioned Stimuli Cereb Cortex, August 1, 2008; 18(8): 1961 - 1972. [Abstract] [Full Text] [PDF]

				S. A. Taha, S. M. Nicola, and H. L. Fields Cue-evoked encoding of movement planning and execution in the rat nucleus accumbens J. Physiol., November 1, 2007; 584(3): 801 - 818. [Abstract] [Full Text] [PDF]

				S. L. Lambourne, T. Humby, A. R. Isles, P. C. Emson, M. G. Spillantini, and L. S. Wilkinson Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age Hum. Mol. Genet., July 15, 2007; 16(14): 1708 - 1719. [Abstract] [Full Text] [PDF]

				A. E. Block, H. Dhanji, S. F. Thompson-Tardif, and S. B. Floresco Thalamic-Prefrontal Cortical-Ventral Striatal Circuitry Mediates Dissociable Components of Strategy Set Shifting Cereb Cortex, July 1, 2007; 17(7): 1625 - 1636. [Abstract] [Full Text] [PDF]

				K. Lasek, R. Lencer, C. Gaser, J. Hagenah, U. Walter, A. Wolters, N. Kock, S. Steinlechner, M. Nagel, C. Zuhlke, et al. Morphological basis for the spectrum of clinical deficits in spinocerebellar ataxia 17 (SCA17) Brain, September 1, 2006; 129(9): 2341 - 2352. [Abstract] [Full Text] [PDF]

				H. Huang, P. Ghosh, and A. N. van den Pol Prefrontal Cortex-Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal J Neurophysiol, March 1, 2006; 95(3): 1656 - 1668. [Abstract] [Full Text] [PDF]

				S. Taverna, B. Canciani, and C. M. A. Pennartz Dopamine D1-Receptors Modulate Lateral Inhibition Between Principal Cells of the Nucleus Accumbens J Neurophysiol, March 1, 2005; 93(3): 1816 - 1819. [Abstract] [Full Text] [PDF]

				D. W. Self, K.-H. Choi, D. Simmons, J. R. Walker, and C. S. Smagula Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration Learn. Mem., September 1, 2004; 11(5): 648 - 657. [Abstract] [Full Text] [PDF]

				P. Di Ciano and B. J. Everitt Direct Interactions between the Basolateral Amygdala and Nucleus Accumbens Core Underlie Cocaine-Seeking Behavior by Rats J. Neurosci., August 11, 2004; 24(32): 7167 - 7173. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help