QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 13, 2004, 24(41):9049-9058; doi:10.1523/JNEUROSCI.2409-04.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (25) Citing Articles via Google Scholar Google Scholar Articles by Fischer, Q. S. Articles by Daw, N. W. Search for Related Content PubMed PubMed Citation Articles by Fischer, Q. S. Articles by Daw, N. W. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Requirement for the RII Isoform of PKA, But Not Calcium-Stimulated Adenylyl Cyclase, in Visual Cortical Plasticity

Quentin S. Fischer,¹ Christopher J. Beaver,¹ Yupeng Yang,¹ Yan Rao,¹ Klara B. Jakobsdottir,¹ Daniel R. Storm,² G. Stanley McKnight,² and Nigel W. Daw¹

¹Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, and ²Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195

The cAMP-dependent protein kinase (PKA) signaling pathway plays a key role in visual cortical plasticity. Inhibitors that block activation of all PKA regulatory subunits (RI,RI, RII, RII) abolish long-term potentiation (LTP) and long-term depression (LTD) in vitro and ocular dominance plasticity (ODP) in vivo. The details of this signaling cascade, however, including the source of PKA signals and which PKA subunits are involved, are unknown. To investigate these issues we have examined LTP, LTD, and ODP in knock-out mice lacking either the two cortically expressed Ca²⁺-stimulated adenylyl cyclases (AC1 and AC8) or the predominant neocortical subunit of PKA (RII). Here we show that plasticity remains intact in AC1/AC8-/- mice, whereas ODP and LTD, but not LTP, are absent in RII-/- mice. We conclude that (1) plasticity in the visual cortex does not require the activity of known Ca²⁺-stimulated adenylyl cyclases, (2) the PKA dependence of ODP and LTD, but not LTP, is mediated by RII-PKA, and (3) multiple isoforms of PKA contribute to LTD.

Key words: cAMP-dependent protein kinase; LTP; LTD; ocular dominance plasticity; monocular deprivation; visual cortex

---

Received June 18, 2004; revised September 5, 2004; accepted September 6, 2004.

This article has been cited by other articles:

				G. B Smith, A. J Heynen, and M. F Bear Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex Phil Trans R Soc B, February 12, 2009; 364(1515): 357 - 367. [Abstract] [Full Text] [PDF]

				H.-J. Jang, K.-H. Cho, H.-S. Kim, S. J. Hahn, M.-S. Kim, and D.-J. Rhie Age-Dependent Decline in Supragranular Long-Term Synaptic Plasticity by Increased Inhibition During the Critical Period in the Rat Primary Visual Cortex J Neurophysiol, January 1, 2009; 101(1): 269 - 275. [Abstract] [Full Text] [PDF]

				Q. S. Fischer, S. Aleem, H. Zhou, and T. A. Pham Adult visual experience promotes recovery of primary visual cortex from long-term monocular deprivation Learn. Mem., August 29, 2007; 14(9): 573 - 580. [Abstract] [Full Text] [PDF]

				Q. S. Fischer, A. Graves, S. Evans, M. E. Lickey, and T. A. Pham Monocular deprivation in adult mice alters visual acuity and single-unit activity Learn. Mem., April 6, 2007; 14(4): 277 - 286. [Abstract] [Full Text] [PDF]

				R. F. Watson, R. M. Abdel-Majid, M. W. Barnett, B. S. Willis, A. Katsnelson, T. H. Gillingwater, G. S. McKnight, P. C. Kind, and P. E. Neumann Involvement of protein kinase A in patterning of the mouse somatosensory cortex. J. Neurosci., May 17, 2006; 26(20): 5393 - 5401. [Abstract] [Full Text] [PDF]

				K. J. Bender, C. B. Allen, V. A. Bender, and D. E. Feldman Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex. J. Neurosci., April 19, 2006; 26(16): 4155 - 4165. [Abstract] [Full Text] [PDF]

				M. Inan, H.-C. Lu, M. J. Albright, W.-C. She, and M. C. Crair Barrel map development relies on protein kinase A regulatory subunit IIbeta-mediated cAMP signaling. J. Neurosci., April 19, 2006; 26(16): 4338 - 4349. [Abstract] [Full Text] [PDF]

				S. Navakkode, S. Sajikumar, and J. U. Frey Mitogen-Activated Protein Kinase-Mediated Reinforcement of Hippocampal Early Long-Term Depression by the Type IV-Specific Phosphodiesterase Inhibitor Rolipram and Its Effect on Synaptic Tagging J. Neurosci., November 16, 2005; 25(46): 10664 - 10670. [Abstract] [Full Text] [PDF]

				A. W. McGee, Y. Yang, Q. S. Fischer, N. W. Daw, and S. M. Strittmatter Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor Science, September 30, 2005; 309(5744): 2222 - 2226. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help