WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, November 24, 2004, 24(47):10594-10602; doi:10.1523/JNEUROSCI.2542-04.2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (37)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perrotti, L. I.
Right arrow Articles by Nestler, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perrotti, L. I.
Right arrow Articles by Nestler, E. J.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Induction of {Delta}FosB in Reward-Related Brain Structures after Chronic Stress

Linda I. Perrotti,1 Yuki Hadeishi,2 Paula G. Ulery,1 Michel Barrot,1 Lisa Monteggia,1 Ronald S. Duman,2 and Eric J. Nestler1

1Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, and 2Laboratory of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508

Acute and chronic stress differentially regulate immediate-early gene (IEG) expression in the brain. Although acute stress induces c-Fos and FosB, repeated exposure to stress desensitizes the c-Fos response, but FosB-like immunoreactivity remains high. Several other treatments differentially regulate IEG expression in a similar manner after acute versus chronic exposure. The form of FosB that persists after these chronic treatments has been identified as {Delta}FosB, a splice variant of the fosB gene. This study was designed to determine whether the FosB form induced after chronic stress is also {Delta}FosB and to map the brain regions and identify the cell populations that exhibit this effect. Western blotting, using an antibody that recognizes all Fos family members, revealed that acute restraint stress caused robust induction of c-Fos and full-length FosB, as well as a small induction of {Delta}FosB, in the frontal cortex (fCTX) and nucleus accumbens (NAc). The induction of c-Fos (and to some extent full-length FosB) was desensitized after 10 d of restraint stress, at which point levels of {Delta}FosB were high. A similar pattern was observed after chronic unpredictable stress. By use of immunohistochemistry, we found that chronic restraint stress induced {Delta}FosB expression predominantly in the fCTX, NAc, and basolateral amygdala, with lower levels of induction seen elsewhere. These findings establish that chronic stress induces {Delta}FosB in several discrete regions of the brain. Such induction could contribute to the long-term effects of stress on the brain.

Key words: c-Fos; stress; nucleus accumbens; prefrontal cortex; amygdala; reward

Received Oct 28, 2003; revised September 14, 2004; accepted September 14, 2004.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
C. H. Liu, J. Q. Ren, J. Yang, C.-m. Liu, J. B. Mandeville, B. R. Rosen, P. G. Bhide, Y. Yanagawa, and P. K. Liu
DNA-Based MRI Probes for Specific Detection of Chronic Exposure to Amphetamine in Living Brains
J. Neurosci., August 26, 2009; 29(34): 10663 - 10670.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. R. Campioni, M. Xu, and D. S. McGehee
Stress-Induced Changes in Nucleus Accumbens Glutamate Synaptic Plasticity
J Neurophysiol, June 1, 2009; 101(6): 3192 - 3198.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. A. Winstanley, R. K. Bachtell, D. E.H. Theobald, S. Laali, T. A. Green, A. Kumar, S. Chakravarty, D. W. Self, and E. J. Nestler
Increased Impulsivity during Withdrawal from Cocaine Self-Administration: Role for {Delta}FosB in the Orbitofrontal Cortex
Cereb Cortex, February 1, 2009; 19(2): 435 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
E. J Nestler
Transcriptional mechanisms of addiction: role of {Delta}FosB
Phil Trans R Soc B, October 12, 2008; 363(1507): 3245 - 3255.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. L Wallace, V. Vialou, L. Rios, T. L. Carle-Florence, S. Chakravarty, A. Kumar, D. L. Graham, T. A. Green, A. Kirk, S. D. Iniguez, et al.
The Influence of {Delta}FosB in the Nucleus Accumbens on Natural Reward-Related Behavior
J. Neurosci., October 8, 2008; 28(41): 10272 - 10277.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. A. Winstanley, Q. LaPlant, D. E. H. Theobald, T. A. Green, R. K. Bachtell, L. I. Perrotti, R. J. DiLeone, S. J. Russo, W. J. Garth, D. W. Self, et al.
{Delta}FosB Induction in Orbitofrontal Cortex Mediates Tolerance to Cocaine-Induced Cognitive Dysfunction
J. Neurosci., September 26, 2007; 27(39): 10497 - 10507.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
H. Zhu, M. Lee, S. Agatsuma, and N. Hiroi
Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice
Hum. Mol. Genet., April 1, 2007; 16(7): 820 - 836.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. M. Ulrich-Lai, M. M. Ostrander, I. M. Thomas, B. A. Packard, A. R. Furay, C. M. Dolgas, D. C. Van Hooren, H. F. Figueiredo, N. K. Mueller, D. C. Choi, et al.
Daily Limited Access to Sweetened Drink Attenuates Hypothalamic-Pituitary-Adrenocortical Axis Stress Responses
Endocrinology, April 1, 2007; 148(4): 1823 - 1834.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Oueslati, V. Sgambato-Faure, C. Melon, P. Kachidian, P. Gubellini, M. Amri, L. K.-L. Goff, and P. Salin
High-Frequency Stimulation of the Subthalamic Nucleus Potentiates L-DOPA-Induced Neurochemical Changes in the Striatum in a Rat Model of Parkinson's Disease
J. Neurosci., February 28, 2007; 27(9): 2377 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Olausson, J. D. Jentsch, N. Tronson, R. L. Neve, E. J. Nestler, and J. R. Taylor
{Delta}FosB in the Nucleus Accumbens Regulates Food-Reinforced Instrumental Behavior and Motivation
J. Neurosci., September 6, 2006; 26(36): 9196 - 9204.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. A. Green, I. N. Alibhai, J. D. Hommel, R. J. DiLeone, A. Kumar, D. E. Theobald, R. L. Neve, and E. J. Nestler
Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli.
J. Neurosci., August 9, 2006; 26(32): 8235 - 8242.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. G. Ulery, G. Rudenko, and E. J. Nestler
Regulation of {Delta}FosB Stability by Phosphorylation.
J. Neurosci., May 10, 2006; 26(19): 5131 - 5142.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-