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The Journal of Neuroscience, November 24, 2004, 24(47):10636-10641; doi:10.1523/JNEUROSCI.3206-04.2004

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Behavioral/Systems/Cognitive
Personality Predicts Brain Responses to Cognitive Demands

Veena Kumari,^1,2 Dominic H. ffytche,² Steven C. R. Williams,³ and Jeffrey A. Gray¹ 

¹Department of Psychology, ²Division of Psychological Medicine, and ³Neuroimaging Research Group, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom

Eysenck (1981) proposed that the personality dimension of introversion- extraversion (E) reflects individual differences in a cortical arousal system modulated by reticulothalamic- cortical pathways: it is chronically more active in introverts relative to extraverts and influences cognitive performance in interaction with task parameters. A circuit with connections to this system, including the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate (AC) cortex, has been identified in studies applying functional magnetic resonance imaging (fMRI) to a broad range of cognitive tasks. We examined the influence of E, assessed with the Eysenck Personality Questionnaire-Revised (Eysenck and Eysenck, 1991), in fMRI activity during an "n-back" task involving four memory loads (0-, 1-, 2-, and 3-back) and a rest condition in healthy men. To confirm the specificity of E effects, we also examined the effects of neuroticism and psychoticism (P) scores. We observed that, as predicted by Eysenck's model, the higher the E score, the greater the change in fMRI signal from rest to the 3-back condition in the DLPFC and AC. In addition, E scores were negatively associated with resting fMRI signals in the thalamus and Broca's area extending to Wernicke's area, supporting the hypothesized (negative) relationship between E and resting arousal. P scores negatively correlated with resting fMRI signal in the globus pallidus-putamen, extending previous findings of a negative relationship of schizotypy to striatal activity seen with older neuroimaging modalities to fMRI. These observations suggest that individual differences affect brain responses during cognitive activity and at rest and provide evidence for the hypothesized neurobiological basis of personality.

Key words: arousal; thalamus; frontal; cognitive activity; fMRI; personality

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Received May 18, 2004; revised October 8, 2004; accepted October 8, 2004.

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