QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 24, 2004, 24(47):10652-10659; doi:10.1523/JNEUROSCI.3179-04.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (58) Citing Articles via Google Scholar Google Scholar Articles by Trantham-Davidson, H. Articles by Seamans, J. K. Search for Related Content PubMed PubMed Citation Articles by Trantham-Davidson, H. Articles by Seamans, J. K.

 Previous Article  |  Next Article 

Cellular/Molecular
Mechanisms Underlying Differential D1 versus D2 Dopamine Receptor Regulation of Inhibition in Prefrontal Cortex

Heather Trantham-Davidson, Laurence C. Neely, Antonieta Lavin, and Jeremy K. Seamans

Physiology and Neuroscience Department, Medical University of South Carolina, Charleston, South Carolina 29425

Typically, D1 and D2 dopamine (DA) receptors exert opposing actions on intracellular signaling molecules and often have disparate physiological effects; however, the factors determining preferential activation of D1 versus D2 signaling are not clear. Here, in vitro patch-clamp recordings show that DA concentration is a critical determinant of D1 versus D2 signaling in prefrontal cortex (PFC). Low DA concentrations (<500 nM) enhance IPSCs via D1 receptors, protein kinase A, and cAMP. Higher DA concentrations (>1 µM) decrease IPSCs via the following cascade: D2G_iplatelet-derived growth factor receptorphospholipase CIP₃Ca²⁺dopamine and cAMP-regulated phosphoprotein-32protein phosphatase 1/2AGABA_A. Blockade of any molecule in the D2-linked pathway reveals a D1-mediated increase in IPSCs, suggesting that D1 effects are occluded at higher DA concentrations by this D2-mediated pathway. Thus, DA concentration, by acting through separate signaling cascades, may determine the relative amount of cortical inhibition and thereby differentially regulate the tuning of cortical networks.

Key words: prefrontal cortex; dopamine receptors; PDGFR; inhibition; GABA; DARPP-32

---

Received Aug 3, 2004; revised October 8, 2004; accepted October 9, 2004.

This article has been cited by other articles:

				P. L. Tierney, A. M. Thierry, J. Glowinski, J. M. Deniau, and Y. Gioanni Dopamine Modulates Temporal Dynamics of Feedforward Inhibition in Rat Prefrontal Cortex In Vivo Cereb Cortex, October 1, 2008; 18(10): 2251 - 2262. [Abstract] [Full Text] [PDF]

				G. Akopian, C. Crawford, M. F. Beal, M. Cappelletti, M. W. Jakowec, G. M. Petzinger, L. Zheng, S. L. Gheorghe, C. M. Reichel, R. Chow, et al. Decreased Striatal Dopamine Release Underlies Increased Expression of Long-Term Synaptic Potentiation at Corticostriatal Synapses 24 h after 3-Nitropropionic-Acid-Induced Chemical Hypoxia J. Neurosci., September 17, 2008; 28(38): 9585 - 9597. [Abstract] [Full Text] [PDF]

				X.-H. Ji, X.-H. Cao, C.-L. Zhang, Z.-J. Feng, X.-H. Zhang, L. Ma, and B.-M. Li Pre- and Postsynaptic {beta}-Adrenergic Activation Enhances Excitatory Synaptic Transmission in Layer V/VI Pyramidal Neurons of the Medial Prefrontal Cortex of Rats Cereb Cortex, July 1, 2008; 18(7): 1506 - 1520. [Abstract] [Full Text] [PDF]

				E. Y. Yuen, Q. Jiang, P. Chen, J. Feng, and Z. Yan Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex J. Biol. Chem., June 20, 2008; 283(25): 17194 - 17204. [Abstract] [Full Text] [PDF]

				K.-Y. Li, C. Xiao, M. Xiong, E. Delphin, and J.-H. Ye Nanomolar Propofol Stimulates Glutamate Transmission to Dopamine Neurons: A Possible Mechanism of Abuse Potential? J. Pharmacol. Exp. Ther., April 1, 2008; 325(1): 165 - 174. [Abstract] [Full Text] [PDF]

				H. Trantham-Davidson, S. Kroner, and J. K. Seamans Dopamine Modulation of Prefrontal Cortex Interneurons Occurs Independently of DARPP-32 Cereb Cortex, April 1, 2008; 18(4): 951 - 958. [Abstract] [Full Text] [PDF]

				S. K. Towers and S. Hestrin D1-Like Dopamine Receptor Activation Modulates GABAergic Inhibition But Not Electrical Coupling between Neocortical Fast-Spiking Interneurons J. Neurosci., March 5, 2008; 28(10): 2633 - 2641. [Abstract] [Full Text] [PDF]

				B. Pan, C. J. Hillard, and Q.-s. Liu Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons J. Neurosci., February 6, 2008; 28(6): 1385 - 1397. [Abstract] [Full Text] [PDF]

				P. K. Dash, A. N. Moore, N. Kobori, and J. D. Runyan Molecular activity underlying working memory Learn. Mem., August 9, 2007; 14(8): 554 - 563. [Abstract] [Full Text] [PDF]

				D. C. Rotaru, D. A. Lewis, and G. Gonzalez-Burgos Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons J. Physiol., June 15, 2007; 581(3): 981 - 1000. [Abstract] [Full Text] [PDF]

				S. Bandyopadhyay and J. J. Hablitz Dopaminergic Modulation of Local Network Activity in Rat Prefrontal Cortex J Neurophysiol, June 1, 2007; 97(6): 4120 - 4128. [Abstract] [Full Text] [PDF]

				S. Kroner, L. S. Krimer, D. A. Lewis, and G. Barrionuevo Dopamine Increases Inhibition in the Monkey Dorsolateral Prefrontal Cortex through Cell Type-Specific Modulation of Interneurons Cereb Cortex, May 1, 2007; 17(5): 1020 - 1032. [Abstract] [Full Text] [PDF]

				L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464. [Abstract] [Full Text] [PDF]

				S. B. Floresco and M. T. Tse Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala-Prefrontal Cortical Pathway J. Neurosci., February 21, 2007; 27(8): 2045 - 2057. [Abstract] [Full Text] [PDF]

				D. A. Caruana, R. E. Sorge, J. Stewart, and C. A. Chapman Dopamine Has Bidirectional Effects on Synaptic Responses to Cortical Inputs in Layer II of the Lateral Entorhinal Cortex J Neurophysiol, December 1, 2006; 96(6): 3006 - 3015. [Abstract] [Full Text] [PDF]

				F. Fumagalli, F. Bedogni, A. Frasca, L. Di Pasquale, G. Racagni, and M. A. Riva Corticostriatal Up-Regulation of Activity-Regulated Cytoskeletal-Associated Protein Expression after Repeated Exposure to Cocaine Mol. Pharmacol., November 1, 2006; 70(5): 1726 - 1734. [Abstract] [Full Text] [PDF]

				C. O. Alberto, R. B. Trask, M. E. Quinlan, and M. Hirasawa Bidirectional Dopaminergic Modulation of Excitatory Synaptic Transmission in Orexin Neurons J. Neurosci., September 27, 2006; 26(39): 10043 - 10050. [Abstract] [Full Text] [PDF]

				H. Homayoun and B. Moghaddam Progression of Cellular Adaptations in Medial Prefrontal and Orbitofrontal Cortex in Response to Repeated Amphetamine J. Neurosci., August 2, 2006; 26(31): 8025 - 8039. [Abstract] [Full Text] [PDF]

				E. Congdon and T. Canli The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches. Behav Cogn Neurosci Rev, December 1, 2005; 4(4): 262 - 281. [Abstract] [PDF]

				X. Sun, Y. Zhao, and M. E. Wolf Dopamine Receptor Stimulation Modulates AMPA Receptor Synaptic Insertion in Prefrontal Cortex Neurons J. Neurosci., August 10, 2005; 25(32): 7342 - 7351. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help