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The Journal of Neuroscience, December 8, 2004, 24(49):11127-11136; doi:10.1523/JNEUROSCI.2933-04.2004

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Cellular/Molecular
Boosting of Action Potential Backpropagation by Neocortical Network Activity In Vivo

Jack Waters and Fritjof Helmchen

Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, 69120 Heidelberg, Germany

Action potentials backpropagate into the dendritic trees of pyramidal neurons, reporting output activity to the sites of synaptic input and provoking long-lasting changes in synaptic strength. It is unclear how this retrograde signal is modified by neural network activity. Using whole-cell recordings from somata, apical trunks, and dendritic tuft branches of layer 2/3 pyramidal neurons in vivo, we show that network-driven subthreshold membrane depolarizations ("up states") occur simultaneously throughout the apical dendritic tree. This spontaneous synaptic activity enhances action potential-evoked calcium influx into the distal apical dendrite by promoting action potential backpropagation. Hence, somatic feedback to the dendrites becomes stronger with increasing network activity.

Key words: dendrite; two-photon; calcium; layer 2/3; up state; pyramidal neuron

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Received July 20, 2004; revised October 21, 2004; accepted October 22, 2004.

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