 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, February 4, 2004, 24(5):1200-1211; doi:10.1523/JNEUROSCI.4731-03.2004
Previous Article | Next Article
Behavioral/Systems/Cognitive
Macaque Ventral Premotor Cortex Exerts Powerful Facilitation of Motor Cortex Outputs to Upper Limb Motoneurons
H. Shimazu,1 M. A. Maier,2 G. Cerri,1 P. A. Kirkwood,1 andR. N. Lemon1 1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom, and 2University Paris-VI and Paris-VII and Institut National de la Santé et de la Recherche Médicale U483, 75005 Paris, France
The ventral premotor area (F5) is part of the cortical circuit controlling visuomotor grasp. F5 could influence hand motor function through at least two pathways: corticospinal projections and corticocortical projections to primary motor cortex (M1). We found that stimulation of macaque F5, which by itself evoked little or no detectable corticospinal output, could produce a robust modulation of motor outputs from M1. Arrays of fine microwires were implanted in F5 and M1. During terminal experiments under chloralose anesthesia, single stimuli delivered to M1 electrodes evoked direct (D) and indirect (I1,I2, and I3) corticospinal volleys. In contrast, single F5 shocks were ineffective; double shocks (3 msec separation) evoked small I waves but no D wave. However, when the test (T) M1 shock was conditioned (C) by single or double F5 shocks, there was strong facilitation of I2 and I3 waves from M1, with C–T intervals of <1 msec. Intracellular recordings from 79 arm and hand motoneurons (MNs) revealed no postsynaptic effects from single F5 shocks. In contrast, these stimuli produced a robust facilitation of I2 and I3 EPSPs evoked from M1 (60% of MNs); this was particularly marked in hand muscle MNs (92%). Muscimol injection in M1 reduced I waves from F5 and abolished the F5-induced facilitation of late I waves from M1, and of EPSPs associated with them. Thus, some motor effects evoked from F5 may be mediated by corticocortical inputs to M1 impinging on interneurons generating late corticospinal I waves. Similar mechanisms may allow F5 to modulate grasp-related outputs from M1.
Key words: motor cortex; movement (motion motor activity); premotor; stimulation; corticospinal; monkey
Received Oct 20, 2003; revised December 3, 2003; accepted December 3, 2003.
This article has been cited by other articles:
P. Celnik, B. Webster, D. M. Glasser, and L. G. Cohen
Effects of Action Observation on Physical Training After Stroke
Stroke, June 1, 2008; 39(6): 1814 - 1820.
[Abstract] [Full Text] [PDF]
M. Davare, R. Lemon, and E. Olivier
Selective modulation of interactions between ventral premotor cortex and primary motor cortex during precision grasping in humans
J. Physiol., June 1, 2008; 586(11): 2735 - 2742.
[Abstract] [Full Text] [PDF]
E. Schmidlin, T. Brochier, M. A. Maier, P. A. Kirkwood, and R. N. Lemon
Pronounced Reduction of Digit Motor Responses Evoked from Macaque Ventral Premotor Cortex after Reversible Inactivation of the Primary Motor Cortex Hand Area
J. Neurosci., May 28, 2008; 28(22): 5772 - 5783.
[Abstract] [Full Text] [PDF]
E. Borra, A. Belmalih, R. Calzavara, M. Gerbella, A. Murata, S. Rozzi, and G. Luppino
Cortical Connections of the Macaque Anterior Intraparietal (AIP) Area
Cereb Cortex, May 1, 2008; 18(5): 1094 - 1111.
[Abstract] [Full Text] [PDF]
N. Dancause, V. Duric, S. Barbay, S. B. Frost, A. Stylianou, and R. J. Nudo
An Additional Motor-Related Field in the Lateral Frontal Cortex of Squirrel Monkeys
Cereb Cortex, April 18, 2008; (2008) bhn050v1.
[Abstract] [Full Text] [PDF]
Y. Nishimura, H. Onoe, Y. Morichika, S. Perfiliev, H. Tsukada, and T. Isa
Time-Dependent Central Compensatory Mechanisms of Finger Dexterity After Spinal Cord Injury
Science, November 16, 2007; 318(5853): 1150 - 1155.
[Abstract] [Full Text] [PDF]
G. Prabhu, R. Lemon, and P. Haggard
On-Line Control of Grasping Actions: Object-Specific Motor Facilitation Requires Sustained Visual Input
J. Neurosci., November 14, 2007; 27(46): 12651 - 12654.
[Abstract] [Full Text] [PDF]
K. Kurata
Laterality of Movement-Related Activity Reflects Transformation of Coordinates in Ventral Premotor Cortex and Primary Motor Cortex of Monkeys
J Neurophysiol, October 1, 2007; 98(4): 2008 - 2021.
[Abstract] [Full Text] [PDF]
M. A. Umilta, T. Brochier, R. L. Spinks, and R. N. Lemon
Simultaneous Recording of Macaque Premotor and Primary Motor Cortex Neuronal Populations Reveals Different Functional Contributions to Visuomotor Grasp
J Neurophysiol, July 1, 2007; 98(1): 488 - 501.
[Abstract] [Full Text] [PDF]
G. Koch, M. Fernandez Del Olmo, B. Cheeran, D. Ruge, S. Schippling, C. Caltagirone, and J. C. Rothwell
Focal Stimulation of the Posterior Parietal Cortex Increases the Excitability of the Ipsilateral Motor Cortex
J. Neurosci., June 20, 2007; 27(25): 6815 - 6822.
[Abstract] [Full Text] [PDF]
J. M. Kilner and C. D. Frith
A possible role for primary motor cortex during action observation
PNAS, May 22, 2007; 104(21): 8683 - 8684.
[Full Text] [PDF]
G. Prabhu, M. Voss, T. Brochier, L. Cattaneo, P. Haggard, and R. Lemon
Excitability of human motor cortex inputs prior to grasp
J. Physiol., May 15, 2007; 581(1): 189 - 201.
[Abstract] [Full Text] [PDF]
L. M. Oberman, J. A. Pineda, and V. S. Ramachandran
The human mirror neuron system: A link between action observation and social skills
Soc Cogn Affect Neurosci, March 1, 2007; 2(1): 62 - 66.
[Abstract] [Full Text] [PDF]
E. P. Gardner, J. Y. Ro, K. S. Babu, and S. Ghosh
Neurophysiology of Prehension. II. Response Diversity in Primary Somatosensory (S-I) and Motor (M-I) Cortices
J Neurophysiol, February 1, 2007; 97(2): 1656 - 1670.
[Abstract] [Full Text] [PDF]
N. Dancause, S. Barbay, S. B. Frost, E. J. Plautz, M. Popescu, P. M. Dixon, A. M. Stowe, K. M. Friel, and R. J. Nudo
Topographically Divergent and Convergent Connectivity between Premotor and Primary Motor Cortex
Cereb Cortex, August 1, 2006; 16(8): 1057 - 1068.
[Abstract] [Full Text] [PDF]
P. A. Chouinard and T. Paus
The Primary Motor and Premotor Areas of the Human Cerebral Cortex
Neuroscientist, April 1, 2006; 12(2): 143 - 152.
[Abstract] [PDF]
V. Raos, M.-A. Umilta, A. Murata, L. Fogassi, and V. Gallese
Functional Properties of Grasping-Related Neurons in the Ventral Premotor Area F5 of the Macaque Monkey
J Neurophysiol, February 1, 2006; 95(2): 709 - 729.
[Abstract] [Full Text] [PDF]
N. Dancause, S. Barbay, S. B. Frost, E. J. Plautz, D. Chen, E. V. Zoubina, A. M. Stowe, and R. J. Nudo
Extensive Cortical Rewiring after Brain Injury
J. Neurosci., November 2, 2005; 25(44): 10167 - 10179.
[Abstract] [Full Text] [PDF]
K. Stefan, L. G. Cohen, J. Duque, R. Mazzocchio, P. Celnik, L. Sawaki, L. Ungerleider, and J. Classen
Formation of a Motor Memory by Action Observation
J. Neurosci., October 12, 2005; 25(41): 9339 - 9346.
[Abstract] [Full Text] [PDF]
R. P. Dum and P. L. Strick
Frontal Lobe Inputs to the Digit Representations of the Motor Areas on the Lateral Surface of the Hemisphere
J. Neurosci., February 9, 2005; 25(6): 1375 - 1386.
[Abstract] [Full Text] [PDF]
L. Cattaneo, M. Voss, T. Brochier, G. Prabhu, D. M. Wolpert, and R. N. Lemon
A cortico-cortical mechanism mediating object-driven grasp in humans
PNAS, January 18, 2005; 102(3): 898 - 903.
[Abstract] [Full Text] [PDF]
N. Murase, J. C. Rothwell, R. Kaji, R. Urushihara, K. Nakamura, N. Murayama, T. Igasaki, M. Sakata-Igasaki, T. Mima, A. Ikeda, et al.
Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp
Brain, January 1, 2005; 128(1): 104 - 115.
[Abstract] [Full Text] [PDF]
C. Buhmann, A. Gorsler, T. Baumer, U. Hidding, C. Demiralay, K. Hinkelmann, C. Weiller, H. R. Siebner, and A. Munchau
Abnormal excitability of premotor-motor connections in de novo Parkinson's disease
Brain, December 1, 2004; 127(12): 2732 - 2746.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|