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The Journal of Neuroscience, December 15, 2004, 24(50):11457-11462; doi:10.1523/JNEUROSCI.2702-04.2004

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Behavioral/Systems/Cognitive
Central Structures Necessary and Sufficient for Ingestive and Glycemic Responses to Urocortin I Administration

Derek Daniels,¹ Stacy Markison,² Harvey J. Grill,² and Joel M. Kaplan²

Departments of ¹Animal Biology and ²Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104

CNS delivery of Urocortin I (UcnI), a member of the corticotropin-releasing factor family, suppresses feeding behavior and increases plasma glucose. The sites of action necessary and sufficient for these responses remain unclear. The contribution of the caudal brainstem was explored using chronically maintained decerebrate (CD) and neurologically intact control rats given fourth-ventricle injections of UcnI. Ingestive and glycemic responses were evaluated, and Fos immunoreactivity was measured in the paraventricular nucleus of the hypothalamus (PVN), the parabrachical nucleus (PBN), the rostral ventrolateral medulla (RVLM), and the nucleus of the solitary tract (NTS). CD rats, like the neurologically intact controls, decreased intraoral food intake and had elevated plasma glucose in response to Unc1 injections, indicating that forebrain structures are not required for these behavioral and physiological actions of UcnI. Fos immunohistochemistry, however, revealed notable differences in the pattern of UcnI-induced activation between intact and CD rats. UcnI-related activation was observed in each of the four aforementioned brain areas of neurologically intact rats but only in the NTS of CD rats. The intact behavioral and physiological responses to UcnI in the absence of neural activation in the PVN, PBN, and RVLM help limit the list of structures necessary for the stimulation and mediation of these responses to UcnI and suggest that the NTS may serve as a primary site of UcnI action.

Key words: Urocortin I; CRF; caudal brainstem; hypothalamus; food intake; energy homeostasis

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Received July 7, 2004; revised November 15, 2004; accepted November 16, 2004.

This article has been cited by other articles:

				M. R. Hayes, K. P. Skibicka, and H. J. Grill Caudal Brainstem Processing Is Sufficient for Behavioral, Sympathetic, and Parasympathetic Responses Driven by Peripheral and Hindbrain Glucagon-Like-Peptide-1 Receptor Stimulation Endocrinology, August 1, 2008; 149(8): 4059 - 4068. [Abstract] [Full Text] [PDF]

				V. P. Bakshi, S. M. Newman, S. Smith-Roe, K. A. Jochman, and N. H. Kalin Stimulation of Lateral Septum CRF2 Receptors Promotes Anorexia and Stress-Like Behaviors: Functional Homology to CRF1 Receptors in Basolateral Amygdala J. Neurosci., September 26, 2007; 27(39): 10568 - 10577. [Abstract] [Full Text] [PDF]

				P. Cottone, V. Sabino, T. R. Nagy, D. V. Coscina, and E. P. Zorrilla Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2 J. Physiol., September 1, 2007; 583(2): 487 - 504. [Abstract] [Full Text] [PDF]

				D. Daniels, D. K. Yee, L. F. Faulconbridge, and S. J. Fluharty Divergent Behavioral Roles of Angiotensin Receptor Intracellular Signaling Cascades Endocrinology, December 1, 2005; 146(12): 5552 - 5560. [Abstract] [Full Text] [PDF]

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