 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, January 5, 2005, 25(1):247-251; doi:10.1523/JNEUROSCI.2899-04.2005
Previous Article | Next Article
BRIEF COMMUNICATION
Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,1 Andy Fink,1 Charmaine Lau,1 Diane Pham,1 Ray A. M. Daza,1 Alessandro Bulfone,2 Tom Kowalczyk,1 andRobert F. Hevner1 1Department of Pathology, University of Washington, Seattle, Washington 98195-7470, and 2Stem Cell Research Institute, Istituto Scientifico San Raffaele, 20132 Milan, Italy
The developing neocortex contains two types of progenitor cells for glutamatergic, pyramidal-projection neurons. The first type, radial glia, produce neurons and glia, divide at the ventricular surface, and express Pax6, a homeodomain transcription factor. The second type, intermediate progenitor cells, are derived from radial glia, produce only neurons, and divide away from the ventricular surface. Here we show that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6. Accordingly, Tbr2 expression in progenitor compartments (the subventricular zone and ventricular zone) rises and falls with cortical plate neurogenesis. The subsequent transition from intermediate progenitor cell to postmitotic neuron is marked by downregulation of Tbr2 and upregulation of Tbr1, another T-domain transcription factor. These findings delineate the transcription factor sequence Pax6
Tbr2
Key words: cerebral cortex; eomesodermin; neurogenesis; projection neurons; subventricular zone; ventricular zone
Received July 16, 2004; revised November 18, 2004; accepted November 20, 2004.
This article has been cited by other articles:
F. Luzzati, L. Bonfanti, A. Fasolo, and P. Peretto
DCX and PSA-NCAM Expression Identifies a Population of Neurons Preferentially Distributed in Associative Areas of Different Pallial Derivatives and Vertebrate Species
Cereb Cortex, October 1, 2008; (2008) bhn145v1.
[Abstract] [Full Text] [PDF]
A. Kawaguchi, T. Ikawa, T. Kasukawa, H. R. Ueda, K. Kurimoto, M. Saitou, and F. Matsuzaki
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis
Development, September 15, 2008; 135(18): 3113 - 3124.
[Abstract] [Full Text] [PDF]
S. J. Arnold, G.-J. Huang, A. F.P. Cheung, T. Era, S.-I. Nishikawa, E. K. Bikoff, Z. Molnar, E. J. Robertson, and M. Groszer
The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone
Genes & Dev., September 15, 2008; 22(18): 2479 - 2484.
[Abstract] [Full Text] [PDF]
J. L. Fish, C. Dehay, H. Kennedy, and W. B. Huttner
Making bigger brains-the evolution of neural-progenitor-cell division
J. Cell Sci., September 1, 2008; 121(17): 2783 - 2793.
[Abstract] [Full Text] [PDF]
A. Faedo, G. S. Tomassy, Y. Ruan, H. Teichmann, S. Krauss, S. J. Pleasure, S. Y. Tsai, M.-J. Tsai, M. Studer, and J. L. R. Rubenstein
COUP-TFI Coordinates Cortical Patterning, Neurogenesis, and Laminar Fate and Modulates MAPK/ERK, AKT, and ss-Catenin Signaling
Cereb Cortex, September 1, 2008; 18(9): 2117 - 2131.
[Abstract] [Full Text] [PDF]
X. Liu, K. Hashimoto-Torii, M. Torii, T. F. Haydar, and P. Rakic
The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone
PNAS, August 19, 2008; 105(33): 11802 - 11807.
[Abstract] [Full Text] [PDF]
M. Komada, H. Saitsu, M. Kinboshi, T. Miura, K. Shiota, and M. Ishibashi
Hedgehog signaling is involved in development of the neocortex
Development, August 15, 2008; 135(16): 2717 - 2727.
[Abstract] [Full Text] [PDF]
B. Cubelos, A. Sebastian-Serrano, S. Kim, C. Moreno-Ortiz, J. M. Redondo, C. A. Walsh, and M. Nieto
Cux-2 Controls the Proliferation of Neuronal Intermediate Precursors of the Cortical Subventricular Zone
Cereb Cortex, August 1, 2008; 18(8): 1758 - 1770.
[Abstract] [Full Text] [PDF]
J. A. Siegenthaler, B. A. Tremper-Wells, and M. W. Miller
Foxg1 Haploinsufficiency Reduces the Population of Cortical Intermediate Progenitor Cells: Effect of Increased p21 Expression
Cereb Cortex, August 1, 2008; 18(8): 1865 - 1875.
[Abstract] [Full Text] [PDF]
N. Bayatti, J. A. Moss, L. Sun, P. Ambrose, J. F. H. Ward, S. Lindsay, and G. J. Clowry
A Molecular Neuroanatomical Study of the Developing Human Neocortex from 8 to 17 Postconceptional Weeks Revealing the Early Differentiation of the Subplate and Subventricular Zone
Cereb Cortex, July 1, 2008; 18(7): 1536 - 1548.
[Abstract] [Full Text] [PDF]
S. J. Harrison, R. Nishinakamura, and A. P. Monaghan
Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb
Cereb Cortex, July 1, 2008; 18(7): 1604 - 1617.
[Abstract] [Full Text] [PDF]
N. Osumi, H. Shinohara, K. Numayama-Tsuruta, and M. Maekawa
Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator
Stem Cells, July 1, 2008; 26(7): 1663 - 1672.
[Abstract] [Full Text] [PDF]
Z. Mo and N. Zecevic
Is Pax6 Critical for Neurogenesis in the Human Fetal Brain?
Cereb Cortex, June 1, 2008; 18(6): 1455 - 1465.
[Abstract] [Full Text] [PDF]
R. D. Hodge, T. D. Kowalczyk, S. A. Wolf, J. M. Encinas, C. Rippey, G. Enikolopov, G. Kempermann, and R. F. Hevner
Intermediate Progenitors in Adult Hippocampal Neurogenesis: Tbr2 Expression and Coordinate Regulation of Neuronal Output
J. Neurosci., April 2, 2008; 28(14): 3707 - 3717.
[Abstract] [Full Text] [PDF]
G. Estivill-Torrus, P. Llebrez-Zayas, E. Matas-Rico, L. Santin, C. Pedraza, I. De Diego, I. Del Arco, P. Fernandez-Llebrez, J. Chun, and F. R. De Fonseca
Absence of LPA1 Signaling Results in Defective Cortical Development
Cereb Cortex, April 1, 2008; 18(4): 938 - 950.
[Abstract] [Full Text] [PDF]
C. Jomary and S. E. Jones
Induction of Functional Photoreceptor Phenotype by Exogenous Crx Expression in Mouse Retinal Stem Cells
Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 429 - 437.
[Abstract] [Full Text] [PDF]
M. R. Costa, G. Wen, A. Lepier, T. Schroeder, and M. Gotz
Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex
Development, January 1, 2008; 135(1): 11 - 22.
[Abstract] [Full Text] [PDF]
R. Belvindrah, D. Graus-Porta, S. Goebbels, K.-A. Nave, and U. Muller
1 Integrins in Radial Glia But Not in Migrating Neurons Are Essential for the Formation of Cell Layers in the Cerebral Cortex
J. Neurosci., December 12, 2007; 27(50): 13854 - 13865.
[Abstract] [Full Text] [PDF]
L. Chakrabarti, Z. Galdzicki, and T. F. Haydar
Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome
J. Neurosci., October 24, 2007; 27(43): 11483 - 11495.
[Abstract] [Full Text] [PDF]
M. R. Costa, N. Kessaris, W. D. Richardson, M. Gotz, and C. Hedin-Pereira
The Marginal Zone/Layer I as a Novel Niche for Neurogenesis and Gliogenesis in Developing Cerebral Cortex
J. Neurosci., October 17, 2007; 27(42): 11376 - 11388.
[Abstract] [Full Text] [PDF]
A. J. Bloom, B. R. Miller, J. R. Sanes, and A. DiAntonio
The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons
Genes & Dev., October 15, 2007; 21(20): 2593 - 2606.
[Abstract] [Full Text] [PDF]
H. Tamai, H. Shinohara, T. Miyata, K. Saito, Y. Nishizawa, T. Nomura, and N. Osumi
Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells
Genes Cells, September 1, 2007; 12(9): 983 - 996.
[Abstract] [Full Text] [PDF]
S. C. Noctor, V. Martinez-Cerdeno, and A. R. Kriegstein
Contribution of Intermediate Progenitor Cells to Cortical Histogenesis
Arch Neurol, May 1, 2007; 64(5): 639 - 642.
[Abstract] [Full Text] [PDF]
Z. Mo, A. R. Moore, R. Filipovic, Y. Ogawa, I. Kazuhiro, S. D. Antic, and N. Zecevic
Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors
J. Neurosci., April 11, 2007; 27(15): 4132 - 4145.
[Abstract] [Full Text] [PDF]
M. Manuel, P. A. Georgala, C. B. Carr, S. Chanas, D. A. Kleinjan, B. Martynoga, J. O. Mason, M. Molinek, J. Pinson, T. Pratt, et al.
Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
Development, February 1, 2007; 134(3): 545 - 555.
[Abstract] [Full Text] [PDF]
C. Englund, T. Kowalczyk, R. A. M. Daza, A. Dagan, C. Lau, M. F. Rose, and R. F. Hevner
Unipolar Brush Cells of the Cerebellum Are Produced in the Rhombic Lip and Migrate through Developing White Matter
J. Neurosci., September 6, 2006; 26(36): 9184 - 9195.
[Abstract] [Full Text] [PDF]
V. Fotaki, T. Yu, P. A. Zaki, J. O. Mason, and D. J. Price
Abnormal Positioning of Diencephalic Cell Types in Neocortical Tissue in the Dorsal Telencephalon of Mice Lacking Functional Gli3
J. Neurosci., September 6, 2006; 26(36): 9282 - 9292.
[Abstract] [Full Text] [PDF]
Y. M. Ganat, J. Silbereis, C. Cave, H. Ngu, G. M. Anderson, Y. Ohkubo, L. R. Ment, and F. M. Vaccarino
Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo.
J. Neurosci., August 15, 2006; 26(33): 8609 - 8621.
[Abstract] [Full Text] [PDF]
N. Haubst, E. Georges-Labouesse, A. De Arcangelis, U. Mayer, and M. Gotz
Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes
Development, August 15, 2006; 133(16): 3245 - 3254.
[Abstract] [Full Text] [PDF]
P. Coti Bertrand, J. R. O'Kusky, and S. M. Innis
Maternal Dietary (n-3) Fatty Acid Deficiency Alters Neurogenesis in the Embryonic Rat Brain
J. Nutr., June 1, 2006; 136(6): 1570 - 1575.
[Abstract] [Full Text] [PDF]
L. Nguyen, A. Besson, J. I.-T. Heng, C. Schuurmans, L. Teboul, C. Parras, A. Philpott, J. M. Roberts, and F. Guillemot
p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
Genes & Dev., June 1, 2006; 20(11): 1511 - 1524.
[Abstract] [Full Text] [PDF]
A. J. Fink, C. Englund, R. A. M. Daza, D. Pham, C. Lau, M. Nivison, T. Kowalczyk, and R. F. Hevner
Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip.
J. Neurosci., March 15, 2006; 26(11): 3066 - 3076.
[Abstract] [Full Text] [PDF]
A. J. Barkovich, R. I. Kuzniecky, G. D. Jackson, R. Guerrini, and W. B. Dobyns
A developmental and genetic classification for malformations of cortical development
Neurology, December 27, 2005; 65(12): 1873 - 1887.
[Abstract] [Full Text] [PDF]
Q. Xu, C. P. Wonders, and S. A. Anderson
Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon
Development, November 15, 2005; 132(22): 4987 - 4998.
[Abstract] [Full Text] [PDF]
S. Yamamoto, I. Yoshino, T. Shimazaki, M. Murohashi, R. F. Hevner, I. Lax, H. Okano, M. Shibuya, J. Schlessinger, and N. Gotoh
Essential role of Shp2-binding sites on FRS2{alpha} for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
PNAS, November 1, 2005; 102(44): 15983 - 15988.
[Abstract] [Full Text] [PDF]
Y. Arai, N. Funatsu, K. Numayama-Tsuruta, T. Nomura, S. Nakamura, and N. Osumi
Role of Fabp7, a Downstream Gene of Pax6, in the Maintenance of Neuroepithelial Cells during Early Embryonic Development of the Rat Cortex
J. Neurosci., October 19, 2005; 25(42): 9752 - 9761.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|