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The Journal of Neuroscience, March 16, 2005, 25(11):3002-3008; doi:10.1523/JNEUROSCI.5295-04.2005
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Behavioral/Systems/Cognitive
Separating the Brain Regions Involved in Recollection and Familiarity in Recognition Memory
Andrew P. Yonelinas,1 Leun J. Otten,2 Kendra N. Shaw,1 andMichael D. Rugg3 1Department of Psychology, University of California Davis, Davis, California 95616, 2Institute of Cognitive Neuroscience and Department of Psychology, University College London, London WC1E 6BT, United Kingdom, and 3Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697
The neural substrates of recognition memory retrieval were examined in a functional magnetic resonance imaging study designed to separate activity related to recollection from that related to continuous variations in familiarity. Across a variety of brain regions, the neural signature of recollection was found to be distinct from familiarity, demonstrating that recollection cannot be attributed to familiarity strength. In the prefrontal cortex, an anterior medial region was related to recollection, but lateral regions, including the anterior and dorsolateral prefrontal cortex, were related to familiarity. Along the lateral parietal cortex, two functionally distinct regions were also observed: a lateral parietal/temporal region related to recollection and a more superior parietal region involved in familiarity. Similarly, in medial parietal regions, the posterior cingulate was related to recollection, whereas the precuneus was related to familiarity. The hippocampus was related to recollection, but also exhibited an inverse relationship to familiarity-driven recognition confidence. The results indicate that recollection and familiarity rely on different networks of brain regions and provide insights into the functional roles of different regions involved in episodic recognition memory.
Key words: cingulate; hippocampus; imaging; memory; parietal; prefrontal; recognition; temporal
Received July 28, 2004; revised February 4, 2005; accepted February 4, 2005.
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