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The Journal of Neuroscience, April 27, 2005, 25(17):4252-4259; doi:10.1523/JNEUROSCI.4721-04.2005

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Development/Plasticity/Repair
Long-Term Depression at Olfactory Nerve Synapses

Hiroki Mutoh, Qi Yuan, and Thomas Knöpfel

Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-0198, Japan

The synapses formed by the olfactory nerve (ON) convey sensory information to olfactory glomeruli, the first stage of central odor processing. Morphological and behavioral studies suggest that glomerular odor processing is plastic in neonate rodents. However, long-term synaptic plasticity, a cellular correlate of functional and structural plasticity, has not yet been demonstrated in this system. Here, we report that ONmitral cell (MC) synapses of 5- to 8-d-old mice express long-term depression (LTD) after brief low-frequency ON stimulation. Pharmacological techniques and imaging of presynaptic calcium signals demonstrate that ON-MC LTD is expressed presynaptically and requires the activation of metabotropic glutamate receptors but does not require fast synaptic transmission. LTD at the ON MC synapse is potentially relevant for the establishment, maintenance, and experience-dependent refinement of odor maps in the olfactory bulb.

Key words: calcium (Ca); imaging; olfactory; patch clamp; metabotropic glutamate receptor; plasticity; LTD

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Received Nov 18, 2004; revised March 17, 2005; accepted March 21, 2005.

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