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The Journal of Neuroscience, April 27, 2005, 25(17):4365-4369; doi:10.1523/JNEUROSCI.0178-05.2005

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BRIEF COMMUNICATION
Cholinergic Basal Forebrain Neurons Burst with Theta during Waking and Paradoxical Sleep

Maan Gee Lee,^1,2 Oum K. Hassani,¹ Angel Alonso,¹ and Barbara E. Jones¹

¹Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4, and ²Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, South Korea

It is known that acetylcholine can stimulate activation and promote plasticity in the cerebral cortex, yet it is not known how the cholinergic basal forebrain neurons, which release acetylcholine in the cortex, discharge in relation to natural cortical activity and sleep-wake states. By recording basal forebrain units in association with electroencephalographic activity across the sleep-wake cycle and labeling individual neurons with Neurobiotin for immunohistochemical identification, we show for the first time that cholinergic neurons discharge in bursts at maximal rates during active waking and paradoxical sleep, when gamma and theta electroencephalographic activity are maximal. They virtually cease firing during slow-wave sleep. Notably, their bursting discharge is synchronized with theta oscillations. Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states.

Key words: acetylcholine; cortical activation; gamma; juxtacellular labeling; plasticity; rat

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Received Jan 13, 2005; revised March 1, 2005; accepted March 23, 2005.

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