QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 1, 2005, 25(22):5339-5350; doi:10.1523/JNEUROSCI.0374-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Cardin, J. A. Articles by Contreras, D. Search for Related Content PubMed PubMed Citation Articles by Cardin, J. A. Articles by Contreras, D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Stimulus-Dependent (30-50 Hz) Oscillations in Simple and Complex Fast Rhythmic Bursting Cells in Primary Visual Cortex

Jessica A. Cardin, Larry A. Palmer, and Diego Contreras

Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19106

Oscillatory activity is generated by many neural systems. band (40 Hz) oscillations in the thalamus and cortex occur spontaneously and in response to sensory stimuli. Fast rhythmic bursting (FRB) cells (also called chattering cells) comprise a unique class of cortical neurons that, during depolarization by current injection, intrinsically generate bursts of high-frequency action potentials with an interburst frequency between 30 and 50 Hz. In the present study, we show for the first time that FRB cells in the primary visual cortex can be either simple or complex and are distributed throughout all cortical layers. Strikingly, both simple and complex FRB cells generate spike bursts at frequencies in response to depolarizing current pulses, but only simple FRB cells exhibit a selective, stimulus feature-dependent increase in oscillations in response to visual stimulation. In addition, we find that hyperpolarization does not reduce the relative power of visually evoked oscillations in the V_m response of FRB cells. Our results thus indicate that visually evoked activity in individual simple and complex FRB cells is generated in large part by rhythmic synaptic input, rather than by depolarization-dependent activation of intrinsic properties. Finally, the presence of FRB cells in layer 6 suggests a role for corticothalamic feedback in potentiating thalamic oscillations and facilitating the generation of a corticothalamocortical oscillatory loop. We propose that rather than functioning as pacemakers, FRB cells amplify and distribute stimulus-driven oscillations in the neocortex.

Key words: contrast; intracellular; orientation; in vivo; intrinsic properties; chattering; feature dependent

---

Received Jan 27, 2005; revised April 21, 2005; accepted April 23, 2005.

This article has been cited by other articles:

				A. K. Roopun, M. O. Cunningham, C. Racca, K. Alter, R. D. Traub, and M. A. Whittington Region-Specific Changes in Gamma and Beta2 Rhythms in NMDA Receptor Dysfunction Models of Schizophrenia Schizophr Bull, September 1, 2008; 34(5): 962 - 973. [Abstract] [Full Text] [PDF]

				L. G. Nowak, M. V. Sanchez-Vives, and D. A. McCormick Lack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types Cereb Cortex, May 1, 2008; 18(5): 1058 - 1078. [Abstract] [Full Text] [PDF]

				W. G. Sannita, S. Carozzo, M. Fioretto, S. Garbarino, and C. Martinoli Abnormal Waveform of the Human Pattern VEP: Contribution from Gamma Oscillatory Components Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4534 - 4541. [Abstract] [Full Text] [PDF]

				J. A. Cardin, L. A. Palmer, and D. Contreras Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex J. Neurosci., September 26, 2007; 27(39): 10333 - 10344. [Abstract] [Full Text] [PDF]

				E. P. Bauer, R. Paz, and D. Pare Gamma Oscillations Coordinate Amygdalo-Rhinal Interactions during Learning J. Neurosci., August 29, 2007; 27(35): 9369 - 9379. [Abstract] [Full Text] [PDF]

				M. Pastor, M Valencia, J Artieda, M Alegre, and J. Masdeu Topography of Cortical Activation Differs for Fundamental and Harmonic Frequencies of the Steady-State Visual-Evoked Responses. An EEG and PET H215O Study Cereb Cortex, August 1, 2007; 17(8): 1899 - 1905. [Abstract] [Full Text] [PDF]

				L. Maler Gamma Oscillations, Synaptic Depression, and the Enhancement of Spatiotemporal Processing. Focus on "Global Electrosensory Oscillations Enhance Directional Responses of Midbrain Neurons in Eigenmannia" J Neurophysiol, November 1, 2006; 96(5): 2173 - 2174. [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help