QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 1, 2005, 25(22):5389-5396; doi:10.1523/JNEUROSCI.0955-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (66) Citing Articles via Google Scholar Google Scholar Articles by Wang, B. Articles by You, Z.-B. Search for Related Content PubMed PubMed Citation Articles by Wang, B. Articles by You, Z.-B.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking

Bin Wang, Yavin Shaham, Dawnya Zitzman, Soraya Azari, Roy A. Wise, and Zhi-Bing You

Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224

Footshock stress can reinstate cocaine-seeking behavior through a central action of the stress-associated neurohormone corticotropin-releasing factor (CRF). Here we report (1) that footshock stress releases CRF in the ventral tegmental area (VTA) of the rat brain, (2) that, in cocaine-experienced but not in cocaine-naive rats, this CRF acquires control over local glutamate release, (3) that CRF-induced glutamate release activates the mesocorticolimbic dopamine system, and (4) that, through this circuitry, footshock stress triggers relapse to drug seeking in cocaine-experienced animals. Thus, a long-lasting cocaine-induced neuroadaptation, presumably at the level of glutamate terminals in the VTA, appears to play an important role in stress-induced relapse to drug use. Similar neuroadaptations may be important for the comorbidity between addiction and other stress-related psychiatric disorders.

Key words: stress; addiction; relapse; ventral tegmental area; corticotropin-releasing factor; cocaine

---

Received March 10, 2005; revised April 27, 2005; accepted April 27, 2005.

This article has been cited by other articles:

				J. Hahn, F. W. Hopf, and A. Bonci Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons J. Neurosci., May 20, 2009; 29(20): 6535 - 6544. [Abstract] [Full Text] [PDF]

				J. Stewart Psychological and neural mechanisms of relapse Phil Trans R Soc B, October 12, 2008; 363(1507): 3147 - 3158. [Abstract] [Full Text] [PDF]

				M. J. Wanat, F. W. Hopf, G. D. Stuber, P. E. M. Phillips, and A. Bonci Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih J. Physiol., April 15, 2008; 586(8): 2157 - 2170. [Abstract] [Full Text] [PDF]

				B. B. Land, M. R. Bruchas, J. C. Lemos, M. Xu, E. J. Melief, and C. Chavkin The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin {kappa}-Opioid System J. Neurosci., January 9, 2008; 28(2): 407 - 414. [Abstract] [Full Text] [PDF]

				Z.-B. You, B. Wang, D. Zitzman, S. Azari, and R. A. Wise A Role for Conditioned Ventral Tegmental Glutamate Release in Cocaine Seeking J. Neurosci., September 26, 2007; 27(39): 10546 - 10555. [Abstract] [Full Text] [PDF]

				B. Boutrel, P. J. Kenny, S. E. Specio, R. Martin-Fardon, A. Markou, G. F. Koob, and L. de Lecea Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior PNAS, December 27, 2005; 102(52): 19168 - 19173. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help