 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, June 15, 2005, 25(24):5710-5719; doi:10.1523/JNEUROSCI.0274-05.2005
Previous Article | Next Article
Cellular/Molecular
Conditional Rhythmicity of Ventral Spinal Interneurons Defined by Expression of the Hb9 Homeodomain Protein
Jennifer M. Wilson,1 Robert Hartley,3 David J. Maxwell,3 Andrew J. Todd,3 Ivo Lieberam,4 Julia A. Kaltschmidt,4 Yutaka Yoshida,4 Thomas M. Jessell,4 andRobert M. Brownstone1,2 Departments of 1Anatomy and Neurobiology and 2Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5, 3Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom, and 4Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032
The properties of mammalian spinal interneurons that underlie rhythmic locomotor networks remain poorly described. Using postnatal transgenic mice in which expression of green fluorescent protein is driven by the promoter for the homeodomain transcription factor Hb9, as well as Hb9-lacZ knock-in mice, we describe a novel population of glutamatergic interneurons located adjacent to the ventral commissure from cervical to midlumbar spinal cord levels. Hb9+ interneurons exhibit strong postinhibitory rebound and demonstrate pronounced membrane potential oscillations in response to chemical stimuli that induce locomotor activity. These data provide a molecular and physiological delineation of a small population of ventral spinal interneurons that exhibit homogeneous electrophysiological features, the properties of which suggest that they are candidate locomotor rhythm-generating interneurons.
Key words: locomotion; central pattern generator; transcription factors; conditional bursting; postinhibitory rebound; rhythm generation
Received Jan 19, 2005; revised May 4, 2005; accepted May 6, 2005.
This article has been cited by other articles:
S. R. Soffe, A. Roberts, and W.-C. Li
Defining the excitatory neurons that drive the locomotor rhythm in a simple vertebrate: insights into the origin of reticulospinal control
J. Physiol., October 15, 2009; 587(20): 4829 - 4844.
[Abstract] [Full Text] [PDF]
A. C. Kwan, S. B. Dietz, W. W. Webb, and R. M. Harris-Warrick
Activity of Hb9 Interneurons during Fictive Locomotion in Mouse Spinal Cord
J. Neurosci., September 16, 2009; 29(37): 11601 - 11613.
[Abstract] [Full Text] [PDF]
J. Dyck and S. Gosgnach
Whole Cell Recordings From Visualized Neurons in the Inner Laminae of the Functionally Intact Spinal Cord
J Neurophysiol, July 1, 2009; 102(1): 590 - 597.
[Abstract] [Full Text] [PDF]
T. Prasad, X. Wang, P. A. Gray, and J. A. Weiner
A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster
Development, December 15, 2008; 135(24): 4153 - 4164.
[Abstract] [Full Text] [PDF]
L. Ziskind-Conhaim, L. Wu, and E. P. Wiesner
Persistent Sodium Current Contributes to Induced Voltage Oscillations in Locomotor-Related Hb9 Interneurons in the Mouse Spinal Cord
J Neurophysiol, October 1, 2008; 100(4): 2254 - 2264.
[Abstract] [Full Text] [PDF]
L. Zhang, J. Schessl, M. Werner, C. Bonnemann, G. Xiong, J. Mojsilovic-Petrovic, W. Zhou, A. Cohen, P. Seeburg, H. Misawa, et al.
Role of GluR1 in Activity-Dependent Motor System Development
J. Neurosci., October 1, 2008; 28(40): 9953 - 9968.
[Abstract] [Full Text] [PDF]
S. Tazerart, L. Vinay, and F. Brocard
The Persistent Sodium Current Generates Pacemaker Activities in the Central Pattern Generator for Locomotion and Regulates the Locomotor Rhythm
J. Neurosci., August 20, 2008; 28(34): 8577 - 8589.
[Abstract] [Full Text] [PDF]
C. K. Franz, U. Rutishauser, and V. F. Rafuse
Intrinsic neuronal properties control selective targeting of regenerating motoneurons
Brain, June 1, 2008; 131(6): 1492 - 1505.
[Abstract] [Full Text] [PDF]
K. C. Cowley, E. Zaporozhets, and B. J. Schmidt
Propriospinal neurons are sufficient for bulbospinal transmission of the locomotor command signal in the neonatal rat spinal cord
J. Physiol., March 15, 2008; 586(6): 1623 - 1635.
[Abstract] [Full Text] [PDF]
L. Ziskind-Conhaim and C. A. Hinckley
Hb9 Versus Type 2 Interneurons
J Neurophysiol, February 1, 2008; 99(2): 1044 - 1046.
[Full Text] [PDF]
J. M. Wilson, A. I. Cowan, and R. M. Brownstone
Hb9 Interneurons: Reply to Ziskind-Conhaim and Hinckley
J Neurophysiol, February 1, 2008; 99(2): 1047 - 1049.
[Full Text] [PDF]
P. Han, S. T. Nakanishi, M. A. Tran, and P. J. Whelan
Dopaminergic Modulation of Spinal Neuronal Excitability
J. Neurosci., November 28, 2007; 27(48): 13192 - 13204.
[Abstract] [Full Text] [PDF]
J. M. Wilson, A. I. Cowan, and R. M. Brownstone
Heterogeneous Electrotonic Coupling and Synchronization of Rhythmic Bursting Activity in Mouse Hb9 Interneurons
J Neurophysiol, October 1, 2007; 98(4): 2370 - 2381.
[Abstract] [Full Text] [PDF]
D. G. Stuart
Reflections on integrative and comparative movement neuroscience
Integr. Comp. Biol., October 1, 2007; 47(4): 482 - 504.
[Abstract] [Full Text] [PDF]
S. Tazerart, J.-C. Viemari, P. Darbon, L. Vinay, and F. Brocard
Contribution of Persistent Sodium Current to Locomotor Pattern Generation in Neonatal Rats
J Neurophysiol, August 1, 2007; 98(2): 613 - 628.
[Abstract] [Full Text] [PDF]
K. A. Quinlan and O. Kiehn
Segmental, Synaptic Actions of Commissural Interneurons in the Mouse Spinal Cord
J. Neurosci., June 13, 2007; 27(24): 6521 - 6530.
[Abstract] [Full Text] [PDF]
S. A. Deuchars
Multi-tasking in the spinal cord - do 'sympathetic' interneurones work harder than we give them credit for?
J. Physiol., May 1, 2007; 580(3): 723 - 729.
[Abstract] [Full Text] [PDF]
G. Zhong, M. A. Masino, and R. M. Harris-Warrick
Persistent Sodium Currents Participate in Fictive Locomotion Generation in Neonatal Mouse Spinal Cord
J. Neurosci., April 25, 2007; 27(17): 4507 - 4518.
[Abstract] [Full Text] [PDF]
J. M. Wilson, D. A. Dombeck, M. Diaz-Rios, R. M. Harris-Warrick, and R. M. Brownstone
Two-Photon Calcium Imaging of Network Activity in XFP-Expressing Neurons in the Mouse
J Neurophysiol, April 1, 2007; 97(4): 3118 - 3125.
[Abstract] [Full Text] [PDF]
A. Wallen-Mackenzie, H. Gezelius, M. Thoby-Brisson, A. Nygard, A. Enjin, F. Fujiyama, G. Fortin, and K. Kullander
Vesicular Glutamate Transporter 2 Is Required for Central Respiratory Rhythm Generation But Not for Locomotor Central Pattern Generation.
J. Neurosci., November 22, 2006; 26(47): 12294 - 12307.
[Abstract] [Full Text] [PDF]
M. Smith and J.-F. Perrier
Intrinsic Properties Shape the Firing Pattern of Ventral Horn Interneurons From the Spinal Cord of the Adult Turtle
J Neurophysiol, November 1, 2006; 96(5): 2670 - 2677.
[Abstract] [Full Text] [PDF]
C. A. Hinckley and L. Ziskind-Conhaim
Electrical Coupling between Locomotor-Related Excitatory Interneurons in the Mammalian Spinal Cord.
J. Neurosci., August 15, 2006; 26(33): 8477 - 8483.
[Abstract] [Full Text] [PDF]
I. T. Gordon and P. J. Whelan
Deciphering the organization and modulation of spinal locomotor central pattern generators
J. Exp. Biol., June 1, 2006; 209(11): 2007 - 2014.
[Abstract] [Full Text] [PDF]
H. Nishimaru, C. E. Restrepo, and O. Kiehn
Activity of Renshaw cells during locomotor-like rhythmic activity in the isolated spinal cord of neonatal mice.
J. Neurosci., May 17, 2006; 26(20): 5320 - 5328.
[Abstract] [Full Text] [PDF]
A. Berkowitz, G. L. C. Yosten, and R. M. Ballard
Somato-Dendritic Morphology Predicts Physiology for Neurons That Contribute to Several Kinds of Limb Movements
J Neurophysiol, May 1, 2006; 95(5): 2821 - 2831.
[Abstract] [Full Text] [PDF]
K. P. Carlin, Y. Dai, and L. M. Jordan
Cholinergic and Serotonergic Excitation of Ascending Commissural Neurons in the Thoraco-Lumbar Spinal Cord of the Neonatal Mouse
J Neurophysiol, February 1, 2006; 95(2): 1278 - 1284.
[Abstract] [Full Text] [PDF]
S. J. B. Butt, L. Lundfald, and O. Kiehn
EphA4 defines a class of excitatory locomotor-related interneurons
PNAS, September 27, 2005; 102(39): 14098 - 14103.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|