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The Journal of Neuroscience, June 15, 2005, 25(24):5710-5719; doi:10.1523/JNEUROSCI.0274-05.2005
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Cellular/Molecular
Conditional Rhythmicity of Ventral Spinal Interneurons Defined by Expression of the Hb9 Homeodomain Protein
Jennifer M. Wilson,1 Robert Hartley,3 David J. Maxwell,3 Andrew J. Todd,3 Ivo Lieberam,4 Julia A. Kaltschmidt,4 Yutaka Yoshida,4 Thomas M. Jessell,4 andRobert M. Brownstone1,2 Departments of 1Anatomy and Neurobiology and 2Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5, 3Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom, and 4Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032
The properties of mammalian spinal interneurons that underlie rhythmic locomotor networks remain poorly described. Using postnatal transgenic mice in which expression of green fluorescent protein is driven by the promoter for the homeodomain transcription factor Hb9, as well as Hb9-lacZ knock-in mice, we describe a novel population of glutamatergic interneurons located adjacent to the ventral commissure from cervical to midlumbar spinal cord levels. Hb9+ interneurons exhibit strong postinhibitory rebound and demonstrate pronounced membrane potential oscillations in response to chemical stimuli that induce locomotor activity. These data provide a molecular and physiological delineation of a small population of ventral spinal interneurons that exhibit homogeneous electrophysiological features, the properties of which suggest that they are candidate locomotor rhythm-generating interneurons.
Key words: locomotion; central pattern generator; transcription factors; conditional bursting; postinhibitory rebound; rhythm generation
Received Jan 19, 2005; revised May 4, 2005; accepted May 6, 2005.
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