QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 22, 2005, 25(25):5943-5955; doi:10.1523/JNEUROSCI.1144-05.2005

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (42) Citing Articles via Google Scholar Google Scholar Articles by Ashley, J. Articles by Budnik, V. Search for Related Content PubMed PubMed Citation Articles by Ashley, J. Articles by Budnik, V. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Fasciclin II Signals New Synapse Formation through Amyloid Precursor Protein and the Scaffolding Protein dX11/Mint

James Ashley, ^* Mary Packard, ^* Bulent Ataman, and Vivian Budnik

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324

Cell adhesion molecules (CAMs) have been universally recognized for their essential roles during synapse remodeling. However, the downstream pathways activated by CAMs have remained mostly unknown. Here, we used the Drosophila larval neuromuscular junction to investigate the pathways activated by Fasciclin II (FasII), a transmembrane CAM of the Ig superfamily, during synapse remodeling. We show that the ability of FasII to stimulate or to prevent synapse formation depends on the symmetry of transmembrane FasII levels in the presynaptic and postsynaptic cell and requires the presence of the fly homolog of amyloid precursor protein (APPL). In turn, APPL is regulated by direct interactions with the PDZ (postsynaptic density-95/Discs large/zona occludens-1)-containing protein dX11/Mint/Lin-10, which also regulates synapse expansion downstream of FasII. These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development.

Key words: Fasciclin II; amyloid precursor protein; X11; adhesion; signaling; Drosophila; neuromuscular junction

---

Received March 23, 2005; revised May 11, 2005; accepted May 12, 2005.

This article has been cited by other articles:

				Z. Wang, B. Wang, L. Yang, Q. Guo, N. Aithmitti, Z. Songyang, and H. Zheng Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis J. Neurosci., September 2, 2009; 29(35): 10788 - 10801. [Abstract] [Full Text] [PDF]

				G. Thinakaran and E. H. Koo Amyloid Precursor Protein Trafficking, Processing, and Function J. Biol. Chem., October 31, 2008; 283(44): 29615 - 29619. [Abstract] [Full Text] [PDF]

				C. L. Gatto and K. Broadie Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure Development, August 1, 2008; 135(15): 2637 - 2648. [Abstract] [Full Text] [PDF]

				M. Osterfield, R. Egelund, L. M. Young, and J. G. Flanagan Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system Development, March 15, 2008; 135(6): 1189 - 1199. [Abstract] [Full Text] [PDF]

				C. Mendoza-Topaz, F. Urra, R. Barria, V. Albornoz, D. Ugalde, U. Thomas, E. D. Gundelfinger, R. Delgado, M. Kukuljan, P. D. Sanxaridis, et al. DLGS97/SAP97 Is Developmentally Upregulated and Is Required for Complex Adult Behaviors and Synapse Morphology and Function J. Neurosci., January 2, 2008; 28(1): 304 - 314. [Abstract] [Full Text] [PDF]

				Y. Bai, K. Markham, F. Chen, R. Weerasekera, J. Watts, P. Horne, Y. Wakutani, R. Bagshaw, P. M. Mathews, P. E. Fraser, et al. The in Vivo Brain Interactome of the Amyloid Precursor Protein Mol. Cell. Proteomics, January 1, 2008; 7(1): 15 - 34. [Abstract] [Full Text] [PDF]

				J. Rohrbough, E. Rushton, E. Woodruff III, T. Fergestad, K. Vigneswaran, and K. Broadie Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation Genes & Dev., October 15, 2007; 21(20): 2607 - 2628. [Abstract] [Full Text] [PDF]

				D. Gorczyca, J. Ashley, S. Speese, N. Gherbesi, U. Thomas, E. Gundelfinger, L. S. Gramates, and V. Budnik Postsynaptic Membrane Addition Depends on the Discs-Large-Interacting t-SNARE Gtaxin J. Neurosci., January 31, 2007; 27(5): 1033 - 1044. [Abstract] [Full Text] [PDF]

				B. Ataman, J. Ashley, D. Gorczyca, M. Gorczyca, D. Mathew, C. Wichmann, S. J. Sigrist, and V. Budnik Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP PNAS, May 16, 2006; 103(20): 7841 - 7846. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help