QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 13, 2005, 25(28):6509-6519; doi:10.1523/JNEUROSCI.1211-05.2005

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Gordon, J. A. Articles by Hen, R. Search for Related Content PubMed PubMed Citation Articles by Gordon, J. A. Articles by Hen, R.

 Previous Article  |  Next Article 

Neurobiology of Disease
State-Dependent Alterations in Hippocampal Oscillations in Serotonin 1A Receptor-Deficient Mice

Joshua A. Gordon,^1,2,4 Clay O. Lacefield,¹ Clifford G. Kentros,⁵ and Rene Hen^1,2,3,4

¹Center for Neurobiology and Behavior, Departments of ²Psychiatry and ³Pharmacology, Columbia University, New York, New York 10032, ⁴New York State Psychiatric Institute, New York, New York 10032, and ⁵Institute of Neuroscience, Department of Psychology, University of Oregon, Eugene, Oregon 97403

Mice lacking the serotonin 1A receptor (5-HT_1AR) show increased levels of anxiety-related behavior across multiple tests and background strains. Tissue-specific rescue experiments, lesion studies, and neurophysiological findings all point toward the hippocampus as a potential mediator of the phenotype. Serotonin, acting through 5-HT_1ARs, can suppress hippocampal theta-frequency oscillations, suggesting that theta oscillations might be increased in the knock-outs. To test this hypothesis, local field potential recordings were obtained from the hippocampus of awake, behaving knock-outs and wild-type littermates. The magnitude of theta oscillations was increased in the knock-outs, specifically in the anxiety-provoking elevated plus maze and not in a familiar environment or during rapid eye movement sleep. Theta power correlated with the fraction of time spent in the open arms, an anxiety-related behavioral variable. These results suggest a possible role for the hippocampus, and theta oscillations in particular, in the expression of anxiety in 5-HT_1AR-deficient mice.

Key words: anxiety; theta rhythm; knock-out; 5-HT_1A receptor; ripple oscillations; awake behaving recording

---

Received March 29, 2005; revised May 26, 2005; accepted May 31, 2005.

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help