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The Journal of Neuroscience, January 19, 2005, 25(3):711-722; doi:10.1523/JNEUROSCI.4034-04.2005
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Behavioral/Systems/Cognitive
Correlation between Speed Perception and Neural Activity in the Middle Temporal Visual Area
Jing Liu andWilliam T. Newsome Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305-5125
We conducted electrophysiological recording and microstimulation experiments to test the hypothesis that the middle temporal visual area (MT) plays a direct role in perception of the speed of moving visual stimuli. We trained rhesus monkeys on a speed discrimination task in which monkeys chose the faster speed of two moving random dot patterns presented simultaneously in spatially segregated apertures. In electrophysiological experiments, we analyzed the activity of speed-tuned MT neurons and multiunit clusters during the discrimination task. Neural activity was correlated with the monkeys' behavioral choices on a trial-to-trial basis (choice probability), and the correlation was predicted by the speed-tuning properties of each unit. In microstimulation experiments, we activated clusters of MT neurons with homogeneous speed-tuning properties during the same speed discrimination task. In one monkey, microstimulation biased speed judgments toward the preferred speed of the stimulated neurons. Together, evidence from these two experiments suggests that MT neurons play a direct role in the perception of visual speed. Comparison of psychometric and neurometric thresholds revealed that single and multineuronal signals were, on average, considerably less sensitive than were the monkeys perceptually, suggesting that signals must be pooled across neurons to account for performance.
Key words: MT; speed; choice probability; microstimulation; neurometric threshold; training effects
Received July 19, 2004; revised December 1, 2004; accepted December 1, 2004.
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