QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 3, 2005, 25(31):7260-7267; doi:10.1523/JNEUROSCI.1641-05.2005

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (26) Citing Articles via Google Scholar Google Scholar Articles by Uncapher, M. R. Articles by Rugg, M. D. Search for Related Content PubMed PubMed Citation Articles by Uncapher, M. R. Articles by Rugg, M. D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Encoding and the Durability of Episodic Memory: A Functional Magnetic Resonance Imaging Study

Melina R. Uncapher and Michael D. Rugg

Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-3800

Memories vary in their durability even when encoding conditions apparently remain constant. We investigated whether, under these circumstances, memory durability is nonetheless associated with variation in the neural activity elicited during encoding. Event-related functional magnetic resonance imaging data were acquired while volunteers semantically classified visually presented words. Using the "remember/know" procedure, memory for one-half of the words was tested after 30 min and for the remaining half after 48 h. In several regions, including left hippocampus and left dorsal inferior frontal gyrus (IFG), activity at encoding differed depending on whether items were later recollected regardless of study-test delay. Delay-selective effects were also evident, however. Recollection after 48 h was associated with enhanced activity in bilateral ventral IFG, whereas recollection after 30 min was associated with greater fusiform activity. Thus, there is a relationship between the neural activity elicited by an event as it is encoded and the durability of the resulting memory representation.

Key words: encoding; memory strength; episodic memory; fMRI; subsequent memory effects; long-term memory

---

Received Feb 24, 2005; revised June 12, 2005; accepted July 3, 2005.

This article has been cited by other articles:

				J. T. Wixted Remember/Know judgments in cognitive neuroscience: An illustration of the underrepresented point of view Learn. Mem., June 19, 2009; 16(7): 406 - 412. [Abstract] [Full Text] [PDF]

				S. Duverne, S. Motamedinia, and M. D. Rugg The Relationship between Aging, Performance, and the Neural Correlates of Successful Memory Encoding Cereb Cortex, March 1, 2009; 19(3): 733 - 744. [Abstract] [Full Text] [PDF]

				H. Park, M. R. Uncapher, and M. D. Rugg Effects of study task on the neural correlates of source encoding Learn. Mem., May 29, 2008; 15(6): 417 - 425. [Abstract] [Full Text] [PDF]

				U. Hasson, H. C. Nusbaum, and S. L. Small Brain Networks Subserving the Extraction of Sentence Information and Its Encoding to Memory Cereb Cortex, December 1, 2007; 17(12): 2899 - 2913. [Abstract] [Full Text] [PDF]

				L. J. Otten Fragments of a Larger Whole: Retrieval Cues Constrain Observed Neural Correlates of Memory Encoding Cereb Cortex, September 1, 2007; 17(9): 2030 - 2038. [Abstract] [Full Text] [PDF]

				R. S. Blumenfeld and C. Ranganath Prefrontal Cortex and Long-Term Memory Encoding: An Integrative Review of Findings from Neuropsychology and Neuroimaging Neuroscientist, June 1, 2007; 13(3): 280 - 291. [Abstract] [PDF]

				R. S. Blumenfeld and C. Ranganath Dorsolateral Prefrontal Cortex Promotes Long-Term Memory Formation through Its Role in Working Memory Organization J. Neurosci., January 18, 2006; 26(3): 916 - 925. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help