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The Journal of Neuroscience, August 3, 2005, 25(31):7268-7277; doi:10.1523/JNEUROSCI.2072-05.2005

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Development/Plasticity/Repair
The Caudal Migratory Stream: A Novel Migratory Stream of Interneurons Derived from the Caudal Ganglionic Eminence in the Developing Mouse Forebrain

Masato Yozu,¹ Hidenori Tabata,¹ and Kazunori Nakajima^1,2

¹Department of Anatomy, Keio University School of Medicine, Tokyo 160-8582, Japan, and ²Department of Molecular Neurobiology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo 105-8461, Japan

The migratory paths of interneurons derived from the ganglionic eminence (GE), and particularly its caudal portion (CGE), remain essentially unknown. To clarify the three-dimensional migration profile of interneurons derived from each part of the GE, we developed a technique involving focal electroporation into a small, defined portion of the telencephalic hemisphere. While the medial GE cells migrated laterally and spread widely throughout the cortex, the majority of the CGE cells migrated caudally toward the caudal-most end of the telencephalon. Time-lapse imaging and an in vivo immunohistochemical study confirmed the existence of a migratory stream depicted by a population of CGE cells directed caudally that eventually reached the hippocampus. Transplantation experiments suggested that the caudal direction of migration of the CGE cells was intrinsically determined as early as embryonic day 13.5. The caudal migratory stream is a novel migratory path for a population of CGE-derived interneurons passing from the subpallium to the hippocampus.

Key words: GABAergic interneurons; cortical development; neuronal migration; medial ganglionic eminence; caudal ganglionic eminence; electroporation

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Received May 23, 2005; revised June 24, 2005; accepted June 29, 2005.

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