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The Journal of Neuroscience, August 24, 2005, 25(34):7771-7779; doi:10.1523/JNEUROSCI.1762-05.2005

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Behavioral/Systems/Cognitive
Existing Motor State Is Favored at the Expense of New Movement during 13-35 Hz Oscillatory Synchrony in the Human Corticospinal System

Thomas Gilbertson,¹ Elodie Lalo,^1,2 Louise Doyle,¹ Vincenzo Di Lazzaro,³ Beatrice Cioni,⁴ and Peter Brown¹

¹Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom, ² Equipe d'accueil en Sciences du Sport, Université Marc Bloch, de Strasbourg II, F67084, France, and Institutes of ³Neurology and ⁴Neurosurgery, Università Cattolica, 00168 Rome, Italy

Oscillations in local field potentials in the -frequency band (13-35 Hz) are a pervasive feature of human and nonhuman primate motor cortical areas. However, the function of such synchronous activity across populations of neurons remains unknown. Here, we test the hypothesis that activity may promote existing motor set and posture while compromising processing related to new movements. Three experiments were performed. First, healthy subjects were instructed to make reaction time movements of the outstretched index finger in response to imperative cues triggered by transient increases in corticospinal synchrony, as evidenced by phasic elevations of -frequency band microtremor and intermuscular synchrony. Second, healthy subjects were instructed to resist a stretch to the index finger triggered in the same way. Finger acceleration in the reaction time task and transcortical components of the stretch reflex were measured and compared with those elicited by random cue or stretch presentation. Finally, we sought a correlation between finger acceleration in the reaction time task and cortical synchrony directly measured from the electrocorticogram in two patients undergoing functional neurosurgery. We demonstrate that movements are slowed and transcortical responses to stretch are potentiated during periods of elevated -band cortical synchrony. The results suggest that physiological periods of synchrony are associated with a cortical state in which postural set is reinforced, but the speed of new movements impaired. The findings are of relevance to Parkinson's disease, in which subcortical and cortical -band synchronization is exaggerated in the setting of increased tone and slowed movements.

Key words: sensorimotor cortex; oscillatory synchrony; corticospinal system; motor set; transcortical reflexes; voluntary movement

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Received May 3, 2005; revised June 27, 2005; accepted July 15, 2005.

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