QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 31, 2005, 25(35):7979-7985; doi:10.1523/JNEUROSCI.2215-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Kassardjian, C. D. Articles by Broussard, D. M. Search for Related Content PubMed PubMed Citation Articles by Kassardjian, C. D. Articles by Broussard, D. M.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
The Site of a Motor Memory Shifts with Consolidation

Charles D. Kassardjian,¹ Yao-Fang Tan,¹ Ji-Yeon J. Chung,³ Raquel Heskin,³ Michael J. Peterson,³ and Dianne M. Broussard^1,2,3

¹Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8, and ²Division of Neurology, Department of Medicine, and ³Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5T 2S8

The basis for the consolidation of memory is a controversial topic, particularly in the case of motor memory. One view is that motor memory is transferred, partially or completely, to a new location during the consolidation process ("systems consolidation"). We investigated this possibility in a primitive motor system, the vestibulo-ocular reflex (VOR). In the simple circuitry of the VOR, there are relatively few possible storage sites for memory. We partially blocked excitatory neurotransmission in the cerebellar cortex of cats with the glutamate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). If CNQX was injected immediately after 60 min of rotation under conditions that induced a learned decrease in the gain of the VOR, gain was returned to its baseline value. Expression of the new memory could also be disrupted by rotation in darkness, suggesting that consolidation had not taken place; however, after learning had continued for 3 d, expression of the learned change was diminished only slightly by blockade and was unaffected by rotation in darkness. Our interpretation of these results is that learning may take place initially in the cerebellar cortex and that during consolidation, motor memories are converted to a more distributed representation that includes the cerebellar cortex and another site.

Key words: memory consolidation; cerebellum; motor learning; motor systems; vestibular; oculomotor

---

Received June 1, 2005; revised July 15, 2005; accepted July 15, 2005.

This article has been cited by other articles:

				S. Endo, F. Shutoh, T. L. Dinh, T. Okamoto, T. Ikeda, M. Suzuki, S. Kawahara, D. Yanagihara, Y. Sato, K. Yamada, et al. Dual involvement of G-substrate in motor learning revealed by gene deletion PNAS, March 3, 2009; 106(9): 3525 - 3530. [Abstract] [Full Text] [PDF]

				D. Z. Wetmore, E. A. Mukamel, and M. J. Schnitzer Lock-and-Key Mechanisms of Cerebellar Memory Recall Based on Rebound Currents J Neurophysiol, October 1, 2008; 100(4): 2328 - 2347. [Abstract] [Full Text] [PDF]

				H. K. Titley, R. Heskin-Sweezie, J.-Y. J. Chung, C. D. Kassardjian, F. Razik, and D. M. Broussard Rapid Consolidation of Motor Memory in the Vestibuloocular Reflex J Neurophysiol, December 1, 2007; 98(6): 3809 - 3812. [Abstract] [Full Text] [PDF]

				M. Beraneck and K. E. Cullen Activity of Vestibular Nuclei Neurons During Vestibular and Optokinetic Stimulation in the Alert Mouse J Neurophysiol, September 1, 2007; 98(3): 1549 - 1565. [Abstract] [Full Text] [PDF]

				T. Ohyama, W. L. Nores, J. F. Medina, F. A. Riusech, and M. D. Mauk Learning-Induced Plasticity in Deep Cerebellar Nucleus J. Neurosci., December 6, 2006; 26(49): 12656 - 12663. [Abstract] [Full Text] [PDF]

				F. R. Robinson, R. Soetedjo, and C. Noto Distinct Short-Term and Long-Term Adaptation to Reduce Saccade Size in Monkey J Neurophysiol, September 1, 2006; 96(3): 1030 - 1041. [Abstract] [Full Text] [PDF]

				M. Faulstich, A. M. van Alphen, C. Luo, S. du Lac, and C. I. De Zeeuw Oculomotor Plasticity During Vestibular Compensation Does Not Depend on Cerebellar LTD J Neurophysiol, September 1, 2006; 96(3): 1187 - 1195. [Abstract] [Full Text] [PDF]

				P. M Blazquez, Y. Hirata, and S. M. Highstein Chronic Changes in Inputs to Dorsal Y Neurons Accompany VOR Motor Learning J Neurophysiol, March 1, 2006; 95(3): 1812 - 1825. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help