QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 31, 2005, 25(35):8085-8096; doi:10.1523/JNEUROSCI.0693-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Terrazas, A. Articles by McNaughton, B. L. Search for Related Content PubMed PubMed Citation Articles by Terrazas, A. Articles by McNaughton, B. L.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Self-Motion and the Hippocampal Spatial Metric

Alejandro Terrazas,¹ Michael Krause,¹ Peter Lipa,¹ Katalin M. Gothard,² Carol A. Barnes,^1,3,4 and Bruce L. McNaughton^1,2,3

¹Arizona Research Laboratories Division of Neural Systems, Memory and Aging, Departments of ²Physiology, ³Psychology, and ⁴Neurology, University of Arizona, Tucson, Arizona 85724

Self-motion signals are sufficient for animal navigation ("path integration") and for updating hippocampal location-specific firing. The contributions of ambulatory, vestibular, and optic self-motion signals to CA1 unit activity and EEG were studied while rats either walked or drove a car between locations on a circular track (referred to as WALK and CAR, respectively) or experienced pseudomotion, in which the animal was stationary and the environment was rotated (WORLD). Fewer pyramidal cells expressed place fields during CAR and those that did exhibited substantially larger place fields. The number of theta cycles required to traverse a place field increased, whereas the slope of the theta phase of firing versus position function was reduced. The presence and/or location of place fields were not well correlated between conditions. These effects were even more accentuated during WORLD. These results are not explainable by a simple "smearing out" of place fields but, in terms of size of place fields relative to the track size, are comparable with what would be observed if the track circumference was reduced and the animal moved around it at a correspondingly slower speed. Theta (and its 14–18 Hz harmonic) power were dependent on velocity, but the gain of this function was substantially reduced during CAR and WORLD, again as if the rat were moving more slowly. The spatial scale over which the hippocampal population vector is updated appears to be derived primarily from the gain of a self-motion velocity signal with approximately equal components derived from ambulation, vestibular, and optic-flow signals.

Key words: spatial navigation; path integration; vestibular; place cells; theta rhythm; ensemble recordings

---

Received Feb 20, 2005; revised July 22, 2005; accepted July 25, 2005.

This article has been cited by other articles:

				B. J. Clark, A. Sarma, and J. S. Taube Head Direction Cell Instability in the Anterior Dorsal Thalamus after Lesions of the Interpeduncular Nucleus J. Neurosci., January 14, 2009; 29(2): 493 - 507. [Abstract] [Full Text] [PDF]

				K. Diba and G. Buzsaki Hippocampal Network Dynamics Constrain the Time Lag between Pyramidal Cells across Modified Environments J. Neurosci., December 10, 2008; 28(50): 13448 - 13456. [Abstract] [Full Text] [PDF]

				S. M. Montgomery, A. Sirota, and G. Buzsaki Theta and Gamma Coordination of Hippocampal Networks during Waking and Rapid Eye Movement Sleep J. Neurosci., June 25, 2008; 28(26): 6731 - 6741. [Abstract] [Full Text] [PDF]

				C. Geisler, D. Robbe, M. Zugaro, A. Sirota, and G. Buzsaki Hippocampal place cell assemblies are speed-controlled oscillators PNAS, May 8, 2007; 104(19): 8149 - 8154. [Abstract] [Full Text] [PDF]

				A. P. Maurer, S. L. Cowen, S. N. Burke, C. A. Barnes, and B. L. McNaughton Phase Precession in Hippocampal Interneurons Showing Strong Functional Coupling to Individual Pyramidal Cells J. Neurosci., December 27, 2006; 26(52): 13485 - 13492. [Abstract] [Full Text] [PDF]

				N. A. Russell, A. Horii, P. F. Smith, C. L. Darlington, and D. K. Bilkey Lesions of the vestibular system disrupt hippocampal theta rhythm in the rat. J Neurophysiol, July 1, 2006; 96(1): 4 - 14. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help