QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, September 7, 2005, 25(36):8131-8140; doi:10.1523/JNEUROSCI.2278-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Pinto, D. J. Articles by Connors, B. W. Search for Related Content PubMed PubMed Citation Articles by Pinto, D. J. Articles by Connors, B. W.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Initiation, Propagation, and Termination of Epileptiform Activity in Rodent Neocortex In Vitro Involve Distinct Mechanisms

David J. Pinto, Saundra L. Patrick, Wendy C. Huang, and Barry W. Connors

Department of Neuroscience, Brown University, Providence, Rhode Island 02912

Waves of epileptiform activity in neocortex have three phenomenological stages: initiation, propagation, and termination. We use a well studied model of epileptiform activity in vitro to investigate directly the hypothesis that each stage is governed by an independent mechanism within the underlying cortical circuit. Using the partially disinhibited neocortical slice preparation, activity is induced and modulated using neurotransmitter receptor antagonists and is measured using both intracellular recordings and a linear array of extracellular electrodes. We find that initiation depends on both synaptic excitation and inhibition and entails a slow process of recruitment at discrete spatial locations within cortical layer 5 but not layer 2/3. Propagation depends on synaptic excitation but not inhibition and is a fast process that involves neurons across the spatial extent of the slice and in all cortical layers. Termination is modulated by synaptic excitation and inhibition. In space, termination occurs reliably at discrete locations. In time, termination is characterized by a strong depolarizing shift (block) and recovery of neurons in all cortical layers. These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages.

Key words: electrical stimulation; epileptiform; picrotoxin; slice; somatosensory cortex; synaptic transmission; activity waves

---

Received June 3, 2005; revised July 18, 2005; accepted July 19, 2005.

This article has been cited by other articles:

				B. Ahmed, A. Hanazawa, C. Undeman, D. Eriksson, S. Valentiniene, and P. E. Roland Cortical Dynamics Subserving Visual Apparent Motion Cereb Cortex, March 28, 2008; (2008) bhn038v1. [Abstract] [Full Text] [PDF]

				A. J. Trevelyan, T. Baldeweg, W. van Drongelen, R. Yuste, and M. Whittington The Source of Afterdischarge Activity in Neocortical Tonic Clonic Epilepsy J. Neurosci., December 5, 2007; 27(49): 13513 - 13519. [Abstract] [Full Text] [PDF]

				S. Jacobi and E. Moses Variability and Corresponding Amplitude-Velocity Relation of Activity Propagating in One-Dimensional Neural Cultures J Neurophysiol, May 1, 2007; 97(5): 3597 - 3606. [Abstract] [Full Text] [PDF]

				C. Yvon, A. Czarnecki, and J. Streit Riluzole-Induced Oscillations in Spinal Networks J Neurophysiol, May 1, 2007; 97(5): 3607 - 3620. [Abstract] [Full Text] [PDF]

				A. J. Trevelyan, D. Sussillo, and R. Yuste Feedforward Inhibition Contributes to the Control of Epileptiform Propagation Speed J. Neurosci., March 28, 2007; 27(13): 3383 - 3387. [Abstract] [Full Text] [PDF]

				A. Devor, A. Trevelyan, and D. Kleinfeld Is There a Common Origin to Surround-Inhibition as Seen Through Electrical Activity Versus Hemodynamic Changes? Focus on "Duration-Dependent Response in SI to Vibrotactile Stimulation in Squirrel Monkey" J Neurophysiol, March 1, 2007; 97(3): 1880 - 1882. [Full Text] [PDF]

				A. J. Trevelyan, D. Sussillo, B. O. Watson, and R. Yuste Modular Propagation of Epileptiform Activity: Evidence for an Inhibitory Veto in Neocortex J. Neurosci., November 29, 2006; 26(48): 12447 - 12455. [Abstract] [Full Text] [PDF]

				C. V. Stewart and D. Plenz Inverted-U Profile of Dopamine-NMDA-Mediated Spontaneous Avalanche Recurrence in Superficial Layers of Rat Prefrontal Cortex J. Neurosci., August 2, 2006; 26(31): 8148 - 8159. [Abstract] [Full Text] [PDF]

				O. Feinerman and E. Moses Transport of information along unidimensional layered networks of dissociated hippocampal neurons and implications for rate coding. J. Neurosci., April 26, 2006; 26(17): 4526 - 4534. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help