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The Journal of Neuroscience, September 14, 2005, 25(37):8567-8577; doi:10.1523/JNEUROSCI.2493-05.2005

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Neurobiology of Disease
Loss of Mtmr2 Phosphatase in Schwann Cells But Not in Motor Neurons Causes Charcot-Marie-Tooth Type 4B1 Neuropathy with Myelin Outfoldings

Annalisa Bolis,¹ Silvia Coviello,¹ Simona Bussini,¹ Giorgia Dina,² Celia Pardini,³ Stefano Carlo Previtali,² Mariachiara Malaguti,² Paolo Morana,² Ubaldo Del Carro,² Maria Laura Feltri,³ Angelo Quattrini,² Lawrence Wrabetz,³ and Alessandra Bolino¹

¹Dulbecco Telethon Institute, ²Department of Neurology, and ³Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milano, Italy

Mutations in MTMR2, the myotubularin-related 2 gene, cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1). This disorder is characterized by childhood onset of weakness and sensory loss, severely decreased nerve conduction velocity, demyelination in the nerve with myelin outfoldings, and severe functional impairment of affected patients, mainly resulting from loss of myelinated fibers in the nerve. We recently generated Mtmr2-null^neo mice, which show a dysmyelinating neuropathy with myelin outfoldings, thus reproducing human CMT4B1. Mtmr2 is detected in both Schwann cells and neurons, in which it interacts with discs large 1/synapse-associated protein 97 and neurofilament light chain, respectively. Here, we specifically ablated Mtmr2 in either Schwann cells or motor neurons. Disruption of Mtmr2 in Schwann cells produced a dysmyelinating phenotype very similar to that of the Mtmr2-null^neo mouse. Disruption of Mtmr2 in motor neurons does not provoke myelin outfoldings nor axonal defects. We propose that loss of Mtmr2 in Schwann cells, but not in motor neurons, is both sufficient and necessary to cause CMT4B1 neuropathy. Thus, therapeutical approaches might be designed in the future to specifically deliver the Mtmr2 phospholipid phosphatase to Schwann cells in affected nerves.

Key words: neuropathy; myelin; phosphatase; mice; Schwann cell; motor neuron

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Received June 17, 2005; revised August 1, 2005; accepted August 5, 2005.

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