QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 26, 2005, 25(4):936-940; doi:10.1523/JNEUROSCI.4715-04.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Dong, Y. Articles by White, F. J. Search for Related Content PubMed PubMed Citation Articles by Dong, Y. Articles by White, F. J.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
Cocaine-Induced Plasticity of Intrinsic Membrane Properties in Prefrontal Cortex Pyramidal Neurons: Adaptations in Potassium Currents

Yan Dong,^2,3 Fernando J. Nasif,¹ Jennifer J. Tsui,³ William Y. Ju,³ Donald C. Cooper,¹ Xiu-Ti Hu,¹ Robert C. Malenka,³ and Francis J. White¹

Departments of ¹Cellular and Molecular Pharmacology and ²Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, and ³Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304-5485

Drug-induced adaptations in the prefrontal cortex (PFC) contribute to several core aspects of addictive behaviors, but the underlying neuronal processes remain essentially unknown. Here, we demonstrate that repeated in vivo exposure to cocaine persistently reduces the voltage-gated K⁺ current (VGKC) in PFC pyramidal neurons, resulting in enhanced membrane excitability. Analysis of dopamine D₁-class receptor (D₁R)-mediated modulation of VGKC indicates that, despite the absence of direct D₁R stimulation, downstream D₁ signaling (the cAMP/protein kinase A pathway) is increased during withdrawal from chronic cocaine treatment and plays a central role in the drug-induced membrane plasticity in PFC. This long-lasting, cocaine-induced plasticity of membrane excitability in PFC pyramidal neurons may contribute to the impaired decision making and drug craving that characterize cocaine withdrawal.

Key words: cocaine; prefrontal cortex; dopamine; K⁺ current; plasticity; adenylate cyclase

---

Received Sep 21, 2004; accepted December 6, 2004.

This article has been cited by other articles:

				H. Lu, B. Lim, and M.-m. Poo Cocaine Exposure In Utero Alters Synaptic Plasticity in the Medial Prefrontal Cortex of Postnatal Rats J. Neurosci., October 7, 2009; 29(40): 12664 - 12674. [Abstract] [Full Text] [PDF]

				M. Ishikawa, P. Mu, J. T. Moyer, J. A. Wolf, R. M. Quock, N. M. Davies, X.-t. Hu, O. M. Schluter, and Y. Dong Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons J. Neurosci., May 6, 2009; 29(18): 5820 - 5831. [Abstract] [Full Text] [PDF]

				W. Francesconi, F. Berton, V. Repunte-Canonigo, K. Hagihara, D. Thurbon, D. Lekic, S. E. Specio, T. N. Greenwell, S. A. Chen, K. C. Rice, et al. Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis J. Neurosci., April 29, 2009; 29(17): 5389 - 5401. [Abstract] [Full Text] [PDF]

				Y. H. Huang, Y. Lin, T. E. Brown, M.-H. Han, D. B. Saal, R. L. Neve, R. S. Zukin, B. A. Sorg, E. J. Nestler, R. C. Malenka, et al. CREB Modulates the Functional Output of Nucleus Accumbens Neurons: A CRITICAL ROLE OF N-METHYL-D-ASPARTATE GLUTAMATE RECEPTOR (NMDAR) RECEPTORS J. Biol. Chem., February 1, 2008; 283(5): 2751 - 2760. [Abstract] [Full Text] [PDF]

				C.-C. Huang, H.-J. Lin, and K.-S. Hsu Repeated Cocaine Administration Promotes Long-Term Potentiation Induction in Rat Medial Prefrontal Cortex Cereb Cortex, August 1, 2007; 17(8): 1877 - 1888. [Abstract] [Full Text] [PDF]

				D. C. Rotaru, D. A. Lewis, and G. Gonzalez-Burgos Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons J. Physiol., June 15, 2007; 581(3): 981 - 1000. [Abstract] [Full Text] [PDF]

				C.-C. Huang, P.-C. Yang, H.-J. Lin, and K.-S. Hsu Repeated Cocaine Administration Impairs Group II Metabotropic Glutamate Receptor-Mediated Long-Term Depression in Rat Medial Prefrontal Cortex J. Neurosci., March 14, 2007; 27(11): 2958 - 2968. [Abstract] [Full Text] [PDF]

				H.-P. Huang, S.-R. Wang, W. Yao, C. Zhang, Y. Zhou, X.-W. Chen, B. Zhang, W. Xiong, L.-Y. Wang, L.-H. Zheng, et al. Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices PNAS, January 23, 2007; 104(4): 1401 - 1406. [Abstract] [Full Text] [PDF]

				L. Nogueira, P. W. Kalivas, and A. Lavin Long-Term Neuroadaptations Produced by Withdrawal from Repeated Cocaine Treatment: Role of Dopaminergic Receptors in Modulating Cortical Excitability. J. Neurosci., November 22, 2006; 26(47): 12308 - 12313. [Abstract] [Full Text] [PDF]

				H. Homayoun and B. Moghaddam Progression of Cellular Adaptations in Medial Prefrontal and Orbitofrontal Cortex in Response to Repeated Amphetamine J. Neurosci., August 2, 2006; 26(31): 8025 - 8039. [Abstract] [Full Text] [PDF]

				W. Sun and G. V. Rebec Repeated cocaine self-administration alters processing of cocaine-related information in rat prefrontal cortex. J. Neurosci., July 26, 2006; 26(30): 8004 - 8008. [Abstract] [Full Text] [PDF]

				J. D. Peterson, M. E. Wolf, and F. J. White Repeated amphetamine administration decreases D1 dopamine receptor-mediated inhibition of voltage-gated sodium currents in the prefrontal cortex. J. Neurosci., March 22, 2006; 26(12): 3164 - 3168. [Abstract] [Full Text] [PDF]

				C.-C. Huang and K.-S. Hsu Presynaptic Mechanism Underlying cAMP-Induced Synaptic Potentiation in Medial Prefrontal Cortex Pyramidal Neurons Mol. Pharmacol., March 1, 2006; 69(3): 846 - 856. [Abstract] [Full Text] [PDF]

				F. J. Nasif, X.-T. Hu, and F. J. White Repeated Cocaine Administration Increases Voltage-Sensitive Calcium Currents in Response to Membrane Depolarization in Medial Prefrontal Cortex Pyramidal Neurons J. Neurosci., April 6, 2005; 25(14): 3674 - 3679. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help