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The Journal of Neuroscience, October 26, 2005, 25(43):10010-10014; doi:10.1523/JNEUROSCI.3307-05.2005

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BRIEF COMMUNICATION
Tracking the Fear Engram: The Lateral Amygdala Is an Essential Locus of Fear Memory Storage

Glenn E. Schafe,1 Valérie Doyère,2,3 and Joseph E. LeDoux3

1Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, 2Laboratoire de Neurobiologic de l'Apprentissage, de la Mémoire, et de la Communication, Unité Mixte de Recherche 8620, Centre National de la Recherche Scientifique-Université Paris-Sud, 91405 Orsay, France, and 3Center for Neural Science, New York University, New York, New York 10003

Although it is believed that different types of memories are localized in discreet regions of the brain, concrete experimental evidence of the existence of such engrams is often elusive. Despite being one of the best characterized memory systems of the brain, the question of where fear memories are localized in the brain remains a hotly debated issue. Here, we combine site-specific behavioral pharmacology with multisite electrophysiological recording techniques to show that the lateral nucleus of the amygdala, long thought to be critical for the acquisition of fear memories, is also an essential locus of fear memory storage.

Key words: fear conditioning; memory consolidation; amygdala; synaptic plasticity; rat; MAP kinase

Received July 1, 2005; revised September 17, 2005; accepted September 18, 2005.




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