 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, October 26, 2005, 25(43):9883-9892; doi:10.1523/JNEUROSCI.1531-05.2005
Previous Article | Next Article
Cellular/Molecular
Role of Hippocampal Cav1.2 Ca2+ Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory
Sven Moosmang,1 Nicole Haider,1 Norbert Klugbauer,1 Helmuth Adelsberger,1 Nicolas Langwieser,1 Jochen Müller,1 Michael Stiess,1 Else Marais,1 Verena Schulla,1 Lubica Lacinova,1 Sandra Goebbels,2 Klaus-Armin Nave,2 Daniel R. Storm,3 Franz Hofmann,1 andThomas Kleppisch1 1Institut für Pharmakologie und Toxikologie, Technische Universität München, 80802 München, Germany, 2Max-Planck-Institut für Experimentelle Medizin, 37075 Göttingen, Germany, and 3Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280
Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-independent long-term potentiation (LTP) in the hippocampus and its function for memory formation in the behaving animal is limited. NMDAR-independent LTP in the CA1 region is thought to require activity of postsynaptic L-type voltage-dependent Ca2+ channels (Cav1.x), but the underlying channel isoform remains unknown. We evaluated the function of the Cav1.2 L-type Ca2+ channel for spatial learning, synaptic plasticity, and triggering of learning-associated biochemical processes using a mouse line with an inactivation of the CACNA1C (Cav1.2) gene in the hippocampus and neocortex (Cav1.2HCKO). This model shows (1) a selective loss of protein synthesis-dependent NMDAR-independent Schaffer collateral/CA1 late-phase LTP (L-LTP), (2) a severe impairment of hippocampus-dependent spatial memory, and (3) decreased activation of the mitogen-activated protein kinase (MAPK) pathway and reduced cAMP response element (CRE)-dependent transcription in CA1 pyramidal neurons. Our results provide strong evidence for a role of L-type Ca2+ channel-dependent, NMDAR-independent hippocampal L-LTP in the formation of spatial memory in the behaving animal and for a function of the MAPK/CREB (CRE-binding protein) signaling cascade in linking Cav1.2 channel-mediated Ca2+ influx to either process.
Key words: calcium channels; learning; memory; NMDA receptor independent; Cav1.2; synaptic plasticity
Received April 19, 2005; revised September 5, 2005; accepted September 6, 2005.
This article has been cited by other articles:
N. G. van Gemert, D. M. M. Carvalho, H. Karst, S. van der Laan, M. Zhang, O. C. Meijer, J. W. Hell, and M. Joels
Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current
Endocrinology, October 1, 2009; 150(10): 4615 - 4624.
[Abstract] [Full Text] [PDF]
H. K. Kato, A. M. Watabe, and T. Manabe
Non-Hebbian Synaptic Plasticity Induced by Repetitive Postsynaptic Action Potentials
J. Neurosci., September 9, 2009; 29(36): 11153 - 11160.
[Abstract] [Full Text] [PDF]
L. D. Brewer, A. L. S. Dowling, M. A. Curran-Rauhut, P. W. Landfield, N. M. Porter, and E. M. Blalock
Estradiol Reverses a Calcium-Related Biomarker of Brain Aging in Female Rats
J. Neurosci., May 13, 2009; 29(19): 6058 - 6067.
[Abstract] [Full Text] [PDF]
M. J. Sinnegger-Brauns, I. G. Huber, A. Koschak, C. Wild, G. J Obermair, U. Einzinger, J.-C. Hoda, S. B. Sartori, and J. Striessnig
Expression and 1,4-Dihydropyridine-Binding Properties of Brain L-Type Calcium Channel Isoforms
Mol. Pharmacol., February 1, 2009; 75(2): 407 - 414.
[Abstract] [Full Text] [PDF]
V. Di Biase, G. J. Obermair, Z. Szabo, C. Altier, J. Sanguesa, E. Bourinet, and B. E. Flucher
Stable Membrane Expression of Postsynaptic CaV1.2 Calcium Channel Clusters Is Independent of Interactions with AKAP79/150 and PDZ Proteins
J. Neurosci., December 17, 2008; 28(51): 13845 - 13855.
[Abstract] [Full Text] [PDF]
J. A. Blundon and S. S. Zakharenko
Dissecting the Components of Long-Term Potentiation
Neuroscientist, December 1, 2008; 14(6): 598 - 608.
[Abstract] [PDF]
S. N. Sarkar, R.-Q. Huang, S. M. Logan, K. D. Yi, G. H. Dillon, and J. W. Simpkins
Estrogens directly potentiate neuronal L-type Ca2+ channels
PNAS, September 30, 2008; 105(39): 15148 - 15153.
[Abstract] [Full Text] [PDF]
D. P. Seeburg and M. Sheng
Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity
J. Neurosci., June 25, 2008; 28(26): 6583 - 6591.
[Abstract] [Full Text] [PDF]
D. Jeon, I. Song, W. Guido, K. Kim, E. Kim, U. Oh, and H.-S. Shin
Ablation of Ca2+ Channel {beta}3 Subunit Leads to Enhanced N-Methyl-D-aspartate Receptor-dependent Long Term Potentiation and Improved Long Term Memory
J. Biol. Chem., May 2, 2008; 283(18): 12093 - 12101.
[Abstract] [Full Text] [PDF]
G. E. Schafe
Rethinking the role of L-type voltage-gated calcium channels in fear memory extinction
Learn. Mem., April 25, 2008; 15(5): 324 - 325.
[Full Text] [PDF]
R. Waltereit, S. Mannhardt, S. Nescholta, C. Maser-Gluth, and D. Bartsch
Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response
Learn. Mem., April 25, 2008; 15(5): 348 - 356.
[Abstract] [Full Text] [PDF]
P. Busquet, A. Hetzenauer, M. J. Sinnegger-Brauns, J. Striessnig, and N. Singewald
Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear
Learn. Mem., April 25, 2008; 15(5): 378 - 386.
[Abstract] [Full Text] [PDF]
R. N. Saha and S. M. Dudek
Action Potentials: To the Nucleus and Beyond
Experimental Biology and Medicine, April 1, 2008; 233(4): 385 - 393.
[Abstract] [Full Text] [PDF]
L. Liebmann, H. Karst, K. Sidiropoulou, N. van Gemert, O. C. Meijer, P. Poirazi, and M. Joels
Differential Effects of Corticosterone on the Slow Afterhyperpolarization in the Basolateral Amygdala and CA1 Region: Possible Role of Calcium Channel Subunits
J Neurophysiol, February 1, 2008; 99(2): 958 - 968.
[Abstract] [Full Text] [PDF]
Y. Ishikawa, Y. Horii, H. Tamura, and S. Shiosaka
Neuropsin (KLK8)-Dependent and -Independent Synaptic Tagging in the Schaffer-Collateral Pathway of Mouse Hippocampus
J. Neurosci., January 23, 2008; 28(4): 843 - 849.
[Abstract] [Full Text] [PDF]
J. A. White, B. C. McKinney, M. C. John, P. A. Powers, T. J. Kamp, and G. G. Murphy
Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice
Learn. Mem., January 3, 2008; 15(1): 1 - 5.
[Abstract] [Full Text] [PDF]
S. Kim, H.-M. Yun, J.-H. Baik, K. C. Chung, S.-Y. Nah, and H. Rhim
Functional Interaction of Neuronal Cav1.3 L-type Calcium Channel with Ryanodine Receptor Type 2 in the Rat Hippocampus
J. Biol. Chem., November 9, 2007; 282(45): 32877 - 32889.
[Abstract] [Full Text] [PDF]
M. Fuenzalida, D. Fernandez de Sevilla, and W. Buno
Changes of the EPSP Waveform Regulate the Temporal Window for Spike-Timing-Dependent Plasticity
J. Neurosci., October 31, 2007; 27(44): 11940 - 11948.
[Abstract] [Full Text] [PDF]
I. T. Bayazitov, R. J. Richardson, R. G. Fricke, and S. S. Zakharenko
Slow Presynaptic and Fast Postsynaptic Components of Compound Long-Term Potentiation
J. Neurosci., October 24, 2007; 27(43): 11510 - 11521.
[Abstract] [Full Text] [PDF]
H.-G. Wang, M. S. George, J. Kim, C. Wang, and G. S. Pitt
Ca2+/Calmodulin Regulates Trafficking of CaV1.2 Ca2+ Channels in Cultured Hippocampal Neurons
J. Neurosci., August 22, 2007; 27(34): 9086 - 9093.
[Abstract] [Full Text] [PDF]
Y. Lu, Y. Lv, Y. Ye, Y. Wang, Y. Hong, M. E. Fortini, Y. Zhong, and Z. Xie
A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila
FASEB J, August 1, 2007; 21(10): 2368 - 2378.
[Abstract] [Full Text] [PDF]
A. Koschak, G. J. Obermair, F. Pivotto, M. J. Sinnegger-Brauns, J. Striessnig, and D. Pietrobon
Molecular Nature of Anomalous L-Type Calcium Channels in Mouse Cerebellar Granule Cells
J. Neurosci., April 4, 2007; 27(14): 3855 - 3863.
[Abstract] [Full Text] [PDF]
I. Calin-Jageman, K. Yu, R. A. Hall, L. Mei, and A. Lee
Erbin Enhances Voltage-Dependent Facilitation of Cav1.3 Ca2+ Channels through Relief of an Autoinhibitory Domain in the Cav1.3 {alpha}1 Subunit
J. Neurosci., February 7, 2007; 27(6): 1374 - 1385.
[Abstract] [Full Text] [PDF]
A. Katoh, J. A. Jindal, and J. L. Raymond
Motor Deficits in Homozygous and Heterozygous P/Q-Type Calcium Channel Mutants
J Neurophysiol, February 1, 2007; 97(2): 1280 - 1287.
[Abstract] [Full Text] [PDF]
J.-P. Zhao, M. A. Phillips, and M. Constantine-Paton
Long-Term Potentiation in the Juvenile Superior Colliculus Requires Simultaneous Activation of NMDA Receptors and L-type Ca2+ Channels and Reflects Addition of Newly Functional Synapses
J. Neurosci., December 6, 2006; 26(49): 12647 - 12655.
[Abstract] [Full Text] [PDF]
M. Barad
Divide and conquer: An L-type voltage-gated calcium channel subtype finds a role in conditioned fear.
Learn. Mem., September 1, 2006; 13(5): 560 - 561.
[Full Text] [PDF]
C. Erxleben, Y. Liao, S. Gentile, D. Chin, C. Gomez-Alegria, Y. Mori, L. Birnbaumer, and D. L. Armstrong
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices.
PNAS, March 7, 2006; 103(10): 3932 - 3937.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|