QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 7, 2005, 25(49):11433-11443; doi:10.1523/JNEUROSCI.4084-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Choi, S.-Y. Articles by Kirkwood, A. Search for Related Content PubMed PubMed Citation Articles by Choi, S.-Y. Articles by Kirkwood, A.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Se-Young Choi,¹ Jeff Chang,¹ Bin Jiang,¹ Geun-Hee Seol,¹ Sun-Seek Min,¹ Jung-Soo Han,² Hee-Sup Shin,³ Michela Gallagher,² and Alfredo Kirkwood¹

¹Mind/Brain Institute and Department of Neurosciences and ²Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, and ³National CRI Center for Calcium and Learning, Korea Institute of Science and Technology, Cheongryang, Seoul 136-791, Korea

Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of 1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP₃). LTD was also impaired by intracellular application of PLC or IP₃ receptor blockers, and it was absent in mice lacking PLC1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.

Key words: adrenergic; cholinergic; glutamatergic; LTD; plasticity; neuromodulation

---

Received May 20, 2005; revised October 27, 2005; accepted October 29, 2005.

This article has been cited by other articles:

				D. Fulton, M. C. Condro, K. Pearce, and D. L. Glanzman The Potential Role of Postsynaptic Phospholipase C Activity in Synaptic Facilitation and Behavioral Sensitization in Aplysia J Neurophysiol, July 1, 2008; 100(1): 108 - 116. [Abstract] [Full Text] [PDF]

				H. Lee, S. J. Raiker, K. Venkatesh, R. Geary, L. A. Robak, Y. Zhang, H. H. Yeh, P. Shrager, and R. J. Giger Synaptic Function for the Nogo-66 Receptor NgR1: Regulation of Dendritic Spine Morphology and Activity-Dependent Synaptic Strength J. Neurosci., March 12, 2008; 28(11): 2753 - 2765. [Abstract] [Full Text] [PDF]

				H. Sheng, Y. Zhang, J. Sun, L. Gao, B. Ma, J. Lu, and X. Ni Corticotropin-Releasing Hormone (CRH) Depresses N-Methyl-D-Aspartate Receptor-Mediated Current in Cultured Rat Hippocampal Neurons via CRH Receptor Type 1 Endocrinology, March 1, 2008; 149(3): 1389 - 1398. [Abstract] [Full Text] [PDF]

				A. Sarihi, B. Jiang, A. Komaki, K. Sohya, Y. Yanagawa, and T. Tsumoto Metabotropic Glutamate Receptor Type 5-Dependent Long-Term Potentiation of Excitatory Synapses on Fast-Spiking GABAergic Neurons in Mouse Visual Cortex J. Neurosci., January 30, 2008; 28(5): 1224 - 1235. [Abstract] [Full Text] [PDF]

				L. J. Volk, B. E. Pfeiffer, J. R. Gibson, and K. M. Huber Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation J. Neurosci., October 24, 2007; 27(43): 11624 - 11634. [Abstract] [Full Text] [PDF]

				P. A. McCoy and L. L. McMahon Muscarinic Receptor Dependent Long-Term Depression in Rat Visual Cortex Is PKC Independent but Requires ERK1/2 Activation and Protein Synthesis J Neurophysiol, October 1, 2007; 98(4): 1862 - 1870. [Abstract] [Full Text] [PDF]

				A. Young and Q.-Q. Sun Long-Term Modifications in the Strength of Excitatory Associative Inputs in the Piriform Cortex Chem Senses, October 1, 2007; 32(8): 783 - 794. [Abstract] [Full Text] [PDF]

				B. Jiang, M. Trevino, and A. Kirkwood Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex J. Neurosci., September 5, 2007; 27(36): 9648 - 9652. [Abstract] [Full Text] [PDF]

				E. A. Horne and M. L. Dell'Acqua Phospholipase C Is Required for Changes in Postsynaptic Structure and Function Associated with NMDA Receptor-Dependent Long-Term Depression J. Neurosci., March 28, 2007; 27(13): 3523 - 3534. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help