QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, February 2, 2005, 25(5):1260-1267; doi:10.1523/JNEUROSCI.3436-04.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Paspalas, C. D. Articles by Goldman-Rakic, P. S. Search for Related Content PubMed PubMed Citation Articles by Paspalas, C. D. Articles by Goldman-Rakic, P. S.

 Previous Article  |  Next Article 

Cellular/Molecular
Presynaptic D₁ Dopamine Receptors in Primate Prefrontal Cortex: Target-Specific Expression in the Glutamatergic Synapse

Constantinos D. Paspalas and Patricia S. Goldman-Rakic 

Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510

Dopaminergic modulation of glutamate neurotransmission in prefrontal cortex (PFC) microcircuits is commonly perceived as a basis for cognitive operations. Yet it appears that although the control of recurrent excitation between deep-layer prefrontal pyramids may involve presynaptic and postsynaptic D₁ receptor (D₁R) mechanisms, pyramid-to-interneuron communication will engage a postsynaptic D₁R component. The substrate underlying such target-specific neuromodulatory patterns was investigated in the infragranular PFC with immunoelectron microscopy for D₁R and parvalbumin, a marker for fast-spiking interneurons. In addition to their proverbial postsynaptic expression, gold-labeled D₁Rs were distinctly distributed on perisynaptic/extrasynaptic membranes and the axoplasm of 13% of excitatory-like, presumably glutamatergic varicosities. Most importantly, presynaptic D₁Rs were highly specific with regard to the cellular compartment and neurochemical identity of the postsynaptic neuron, being present in spine-targeting varicosities but distinctly absent from those synapsing with parvalbumin profiles often coexpressing D₁Rs. We define therein an axonal D₁ heteroreceptor component, apparently mediating volume neurotransmission, yet strategically positioned to convey target cell-specific modulation of the glutamatergic drive. We also indicate that presynaptic D₁R mechanisms may indeed be associated with recurrent excitation in prefrontal microcircuits, consistent with physiological evidence for a role of these receptors in modulating the persistent activity-profile of neurons essential for working memory.

Key words: dopamine D₁ receptor; glutamate; parvalbumin; presynaptic; prefrontal cortex; recurrent excitation; persistent activity; working memory

---

Received Aug 20, 2004; revised December 16, 2004; accepted December 17, 2004.

This article has been cited by other articles:

				C. D. Paspalas, C. C. Perley, D. V. Venkitaramani, S. M. Goebel-Goody, Y. Zhang, P. Kurup, J. H. Mattis, and P. J. Lombroso Major Vault Protein is Expressed along the Nucleus-Neurite Axis and Associates with mRNAs in Cortical Neurons Cereb Cortex, November 21, 2008; (2008) bhn203v1. [Abstract] [Full Text] [PDF]

				J. R. Glausier, Z. U. Khan, and E. C. Muly Dopamine D1 and D5 Receptors Are Localized to Discrete Populations of Interneurons in Primate Prefrontal Cortex Cereb Cortex, November 19, 2008; (2008) bhn212v1. [Abstract] [Full Text] [PDF]

				S. K. Towers and S. Hestrin D1-Like Dopamine Receptor Activation Modulates GABAergic Inhibition But Not Electrical Coupling between Neocortical Fast-Spiking Interneurons J. Neurosci., March 5, 2008; 28(10): 2633 - 2641. [Abstract] [Full Text] [PDF]

				L. Orozco-Cabal, J. Liu, S. Pollandt, K. Schmidt, P. Shinnick-Gallagher, and J. P. Gallagher Dopamine and Corticotropin-Releasing Factor Synergistically Alter Basolateral Amygdala-to-Medial Prefrontal Cortex Synaptic Transmission: Functional Switch after Chronic Cocaine Administration J. Neurosci., January 9, 2008; 28(2): 529 - 542. [Abstract] [Full Text] [PDF]

				D. C. Rotaru, D. A. Lewis, and G. Gonzalez-Burgos Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons J. Physiol., June 15, 2007; 581(3): 981 - 1000. [Abstract] [Full Text] [PDF]

				S. Kroner, L. S. Krimer, D. A. Lewis, and G. Barrionuevo Dopamine Increases Inhibition in the Monkey Dorsolateral Prefrontal Cortex through Cell Type-Specific Modulation of Interneurons Cereb Cortex, May 1, 2007; 17(5): 1020 - 1032. [Abstract] [Full Text] [PDF]

				S. B. Floresco and M. T. Tse Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala-Prefrontal Cortical Pathway J. Neurosci., February 21, 2007; 27(8): 2045 - 2057. [Abstract] [Full Text] [PDF]

				G. Gonzalez-Burgos, S. Kroener, J. K. Seamans, D. A. Lewis, and G. Barrionuevo Dopaminergic Modulation of Short-Term Synaptic Plasticity in Fast-Spiking Interneurons of Primate Dorsolateral Prefrontal Cortex J Neurophysiol, December 1, 2005; 94(6): 4168 - 4177. [Abstract] [Full Text] [PDF]

				C. R. Yang and L. Chen Targeting Prefrontal Cortical Dopamine D1 and N-Methyl-D-Aspartate Receptor Interactions in Schizophrenia Treatment Neuroscientist, October 1, 2005; 11(5): 452 - 470. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help