 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, February 9, 2005, 25(6):1375-1386; doi:10.1523/JNEUROSCI.3902-04.2005
Previous Article | Next Article
Behavioral/Systems/Cognitive
Frontal Lobe Inputs to the Digit Representations of the Motor Areas on the Lateral Surface of the Hemisphere
Richard P. Dum1 andPeter L. Strick1,2,3 1Center for the Neural Basis of Cognition and Departments of Neurobiology and 2Neurological Surgery and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, and 3Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240
We examined the frontal lobe connections of the digit representations in the primary motor cortex (M1), the dorsal premotor area (PMd), and the ventral premotor area (PMv) of cebus monkeys. All of these digit representations lie on the lateral surface of the hemisphere. We used intracortical stimulation to identify the digit representations physiologically, and then we injected different tracers into two of the three cortical areas. This approach enabled us to compare the inputs to two digit representations in the same animal. We found that the densest inputs from the premotor areas to the digit representation in M1 originate from the PMd and the PMv. Both of these premotor areas contain a distinct digit representation, and the two digit representations are densely interconnected. Surprisingly, the projections from the digit representation in the supplementary motor area (SMA) to the PMd and PMv are stronger than the SMA projections to M1. The projections from other premotor areas to M1, the PMd, and the PMv are more modest. Of the three digit areas on the lateral surface, only the PMv receives dense input from the prefrontal cortex. Based on these results, we believe that M1, the PMd, and the PMv form a densely interconnected network of cortical areas that is concerned with the generation and control of hand movements. Overall, the laminar origins of neurons that interconnect the three cortical areas are typical of "lateral" interactions. Thus, from an anatomical perspective, this cortical network lacks a clear hierarchical organization.
Key words: brain mapping; dorsal premotor area; hand; prefrontal cortex; primary motor cortex; ventral premotor area
Received Sep 20, 2004; revised December 20, 2004; accepted December 21, 2004.
This article has been cited by other articles:
R. P. Dum, D. J. Levinthal, and P. L. Strick
The Spinothalamic System Targets Motor and Sensory Areas in the Cerebral Cortex of Monkeys
J. Neurosci., November 11, 2009; 29(45): 14223 - 14235.
[Abstract] [Full Text] [PDF]
G. Liuzzi, V. Horniss, J. Hoppe, K. Heise, M. Zimerman, C. Gerloff, and F. C. Hummel
Distinct Temporospatial Interhemispheric Interactions in the Human Primary and Premotor Cortex during Movement Preparation
Cereb Cortex, November 11, 2009; (2009) bhp196v1.
[Abstract] [Full Text] [PDF]
T. R. Makin, N. P. Holmes, C. Brozzoli, Y. Rossetti, and A. Farne
Coding of Visual Space during Motor Preparation: Approaching Objects Rapidly Modulate Corticospinal Excitability in Hand-Centered Coordinates
J. Neurosci., September 23, 2009; 29(38): 11841 - 11851.
[Abstract] [Full Text] [PDF]
M.-H. Boudrias, R. L. McPherson, S. B. Frost, and P. D. Cheney
Output Properties and Organization of the Forelimb Representation of Motor Areas on the Lateral Aspect of the Hemisphere in Rhesus Macaques
Cereb Cortex, June 26, 2009; (2009) bhp084v1.
[Abstract] [Full Text] [PDF]
G. Prabhu, H. Shimazu, G. Cerri, T. Brochier, R. L. Spinks, M. A. Maier, and R. N. Lemon
Modulation of primary motor cortex outputs from ventral premotor cortex during visually guided grasp in the macaque monkey
J. Physiol., March 1, 2009; 587(5): 1057 - 1069.
[Abstract] [Full Text] [PDF]
N. Dancause, V. Duric, S. Barbay, S. B. Frost, A. Stylianou, and R. J. Nudo
An Additional Motor-Related Field in the Lateral Frontal Cortex of Squirrel Monkeys
Cereb Cortex, December 1, 2008; 18(12): 2719 - 2728.
[Abstract] [Full Text] [PDF]
R. L. Spinks, A. Kraskov, T. Brochier, M. A. Umilta, and R. N. Lemon
Selectivity for Grasp in Local Field Potential and Single Neuron Activity Recorded Simultaneously from M1 and F5 in the Awake Macaque Monkey
J. Neurosci., October 22, 2008; 28(43): 10961 - 10971.
[Abstract] [Full Text] [PDF]
E. Stark, A. Globerson, I. Asher, and M. Abeles
Correlations between Groups of Premotor Neurons Carry Information about Prehension
J. Neurosci., October 15, 2008; 28(42): 10618 - 10630.
[Abstract] [Full Text] [PDF]
S. Bestmann, O. Swayne, F. Blankenburg, C. C. Ruff, P. Haggard, N. Weiskopf, O. Josephs, J. Driver, J. C. Rothwell, and N. S. Ward
Dorsal Premotor Cortex Exerts State-Dependent Causal Influences on Activity in Contralateral Primary Motor and Dorsal Premotor Cortex
Cereb Cortex, June 1, 2008; 18(6): 1281 - 1291.
[Abstract] [Full Text] [PDF]
M. Davare, R. Lemon, and E. Olivier
Selective modulation of interactions between ventral premotor cortex and primary motor cortex during precision grasping in humans
J. Physiol., June 1, 2008; 586(11): 2735 - 2742.
[Abstract] [Full Text] [PDF]
E. Schmidlin, T. Brochier, M. A. Maier, P. A. Kirkwood, and R. N. Lemon
Pronounced Reduction of Digit Motor Responses Evoked from Macaque Ventral Premotor Cortex after Reversible Inactivation of the Primary Motor Cortex Hand Area
J. Neurosci., May 28, 2008; 28(22): 5772 - 5783.
[Abstract] [Full Text] [PDF]
E. Borra, A. Belmalih, R. Calzavara, M. Gerbella, A. Murata, S. Rozzi, and G. Luppino
Cortical Connections of the Macaque Anterior Intraparietal (AIP) Area
Cereb Cortex, May 1, 2008; 18(5): 1094 - 1111.
[Abstract] [Full Text] [PDF]
S. Dechaumont-Palacin, P. Marque, X. De Boissezon, E. Castel-Lacanal, C. Carel, I. Berry, J. Pastor, J.F. Albucher, F. Chollet, and I. Loubinoux
Neural Correlates of Proprioceptive Integration in the Contralesional Hemisphere of Very Impaired Patients Shortly After a Subcortical Stroke: An fMRI Study
Neurorehabil Neural Repair, April 1, 2008; 22(2): 154 - 165.
[Abstract] [PDF]
M. A. Umilta, L. Escola, I. Intskirveli, F. Grammont, M. Rochat, F. Caruana, A. Jezzini, V. Gallese, and G. Rizzolatti
When pliers become fingers in the monkey motor system
PNAS, February 12, 2008; 105(6): 2209 - 2213.
[Abstract] [Full Text] [PDF]
A. Suppa, M. Bologna, F. Gilio, C. Lorenzano, J. C. Rothwell, and A. Berardelli
Preconditioning Repetitive Transcranial Magnetic Stimulation of Premotor Cortex Can Reduce But Not Enhance Short-Term Facilitation of Primary Motor Cortex
J Neurophysiol, February 1, 2008; 99(2): 564 - 570.
[Abstract] [Full Text] [PDF]
D. Akkal, R. P. Dum, and P. L. Strick
Supplementary Motor Area and Presupplementary Motor Area: Targets of Basal Ganglia and Cerebellar Output
J. Neurosci., October 3, 2007; 27(40): 10659 - 10673.
[Abstract] [Full Text] [PDF]
J. Padberg, J. G. Franca, D. F. Cooke, J. G. M. Soares, M. G. P. Rosa, M. Fiorani Jr, R. Gattass, and L. Krubitzer
Parallel Evolution of Cortical Areas Involved in Skilled Hand Use
J. Neurosci., September 19, 2007; 27(38): 10106 - 10115.
[Abstract] [Full Text] [PDF]
V. Tomassini, S. Jbabdi, J. C. Klein, T. E. J. Behrens, C. Pozzilli, P. M. Matthews, M. F. S. Rushworth, and H. Johansen-Berg
Diffusion-Weighted Imaging Tractography-Based Parcellation of the Human Lateral Premotor Cortex Identifies Dorsal and Ventral Subregions with Anatomical and Functional Specializations
J. Neurosci., September 19, 2007; 27(38): 10259 - 10269.
[Abstract] [Full Text] [PDF]
A. P. Batista, G. Santhanam, B. M. Yu, S. I. Ryu, A. Afshar, and K. V. Shenoy
Reference Frames for Reach Planning in Macaque Dorsal Premotor Cortex
J Neurophysiol, August 1, 2007; 98(2): 966 - 983.
[Abstract] [Full Text] [PDF]
M. A. Umilta, T. Brochier, R. L. Spinks, and R. N. Lemon
Simultaneous Recording of Macaque Premotor and Primary Motor Cortex Neuronal Populations Reveals Different Functional Contributions to Visuomotor Grasp
J Neurophysiol, July 1, 2007; 98(1): 488 - 501.
[Abstract] [Full Text] [PDF]
G. Koch, M. Fernandez Del Olmo, B. Cheeran, D. Ruge, S. Schippling, C. Caltagirone, and J. C. Rothwell
Focal Stimulation of the Posterior Parietal Cortex Increases the Excitability of the Ipsilateral Motor Cortex
J. Neurosci., June 20, 2007; 27(25): 6815 - 6822.
[Abstract] [Full Text] [PDF]
J. M. Kilner and C. D. Frith
A possible role for primary motor cortex during action observation
PNAS, May 22, 2007; 104(21): 8683 - 8684.
[Full Text] [PDF]
G. Prabhu, M. Voss, T. Brochier, L. Cattaneo, P. Haggard, and R. Lemon
Excitability of human motor cortex inputs prior to grasp
J. Physiol., May 15, 2007; 581(1): 189 - 201.
[Abstract] [Full Text] [PDF]
E. Stark, I. Asher, and M. Abeles
Encoding of Reach and Grasp by Single Neurons in Premotor Cortex Is Independent of Recording Site
J Neurophysiol, May 1, 2007; 97(5): 3351 - 3364.
[Abstract] [Full Text] [PDF]
M. S.A. Graziano and T. N. Aflalo
Rethinking Cortical Organization: Moving Away from Discrete Areas Arranged in Hierarchies
Neuroscientist, April 1, 2007; 13(2): 138 - 147.
[Abstract] [PDF]
W. J. Kargo, B. Szatmary, and D. A. Nitz
Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in Action-Reward Contingencies
J. Neurosci., March 28, 2007; 27(13): 3548 - 3559.
[Abstract] [Full Text] [PDF]
P. van den Hurk, R. B. Mars, G. van Elswijk, J. Hegeman, J. W. Pasman, B. R. Bloem, and I. Toni
Online Maintenance of Sensory and Motor Representations: Effects on Corticospinal Excitability
J Neurophysiol, February 1, 2007; 97(2): 1642 - 1648.
[Abstract] [Full Text] [PDF]
G. Koch, M. Franca, H. Mochizuki, B. Marconi, C. Caltagirone, and J. C. Rothwell
Interactions between pairs of transcranial magnetic stimuli over the human left dorsal premotor cortex differ from those seen in primary motor cortex
J. Physiol., January 15, 2007; 578(2): 551 - 562.
[Abstract] [Full Text] [PDF]
M. M. Churchland, G. Santhanam, and K. V. Shenoy
Preparatory Activity in Premotor and Motor Cortex Reflects the Speed of the Upcoming Reach
J Neurophysiol, December 1, 2006; 96(6): 3130 - 3146.
[Abstract] [Full Text] [PDF]
N. Dancause, S. Barbay, S. B. Frost, E. J. Plautz, M. Popescu, P. M. Dixon, A. M. Stowe, K. M. Friel, and R. J. Nudo
Topographically Divergent and Convergent Connectivity between Premotor and Primary Motor Cortex
Cereb Cortex, August 1, 2006; 16(8): 1057 - 1068.
[Abstract] [Full Text] [PDF]
G. Koch, M. Franca, M. Fernandez Del Olmo, B. Cheeran, R. Milton, M. Alvarez Sauco, and J. C. Rothwell
Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection.
J. Neurosci., July 12, 2006; 26(28): 7452 - 7459.
[Abstract] [Full Text] [PDF]
T. N. Aflalo and M. S. A. Graziano
Possible origins of the complex topographic organization of motor cortex: reduction of a multidimensional space onto a two-dimensional array.
J. Neurosci., June 7, 2006; 26(23): 6288 - 6297.
[Abstract] [Full Text] [PDF]
E. Hoshi and J. Tanji
Differential Involvement of Neurons in the Dorsal and Ventral Premotor Cortex During Processing of Visual Signals for Action Planning
J Neurophysiol, June 1, 2006; 95(6): 3596 - 3616.
[Abstract] [Full Text] [PDF]
P. A. Chouinard and T. Paus
The Primary Motor and Premotor Areas of the Human Cerebral Cortex
Neuroscientist, April 1, 2006; 12(2): 143 - 152.
[Abstract] [PDF]
V. Raos, M.-A. Umilta, A. Murata, L. Fogassi, and V. Gallese
Functional Properties of Grasping-Related Neurons in the Ventral Premotor Area F5 of the Macaque Monkey
J Neurophysiol, February 1, 2006; 95(2): 709 - 729.
[Abstract] [Full Text] [PDF]
S. A. Bunge, J. D. Wallis, A. Parker, M. Brass, E. A. Crone, E. Hoshi, and K. Sakai
Neural Circuitry Underlying Rule Use in Humans and Nonhuman Primates
J. Neurosci., November 9, 2005; 25(45): 10347 - 10350.
[Full Text] [PDF]
N. Dancause, S. Barbay, S. B. Frost, E. J. Plautz, D. Chen, E. V. Zoubina, A. M. Stowe, and R. J. Nudo
Extensive Cortical Rewiring after Brain Injury
J. Neurosci., November 2, 2005; 25(44): 10167 - 10179.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|