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The Journal of Neuroscience, February 9, 2005, 25(6):1599-1609; doi:10.1523/JNEUROSCI.4457-04.2005

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Behavioral/Systems/Cognitive
Comparison of the Effects of Damage to the Perirhinal and Parahippocampal Cortex on Transverse Patterning and Location Memory in Rhesus Macaques

Maria C. Alvarado and Jocelyne Bachevalier

Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas 77030

Monkeys with damage to the parahippocampal (TH/TF) or perirhinal (PRh) cortex were tested on two sets of the transverse patterning (TP) problem (A+/B-, B+/C-, C+/A- and D+/E-, E+/F-, F+/D-) and delayed nonmatching-to-location paradigm (DNML), with delays ranging from 10 to 600 s. Damage to either area impaired acquisition and performance of TP but not of linear discriminations (e.g., A>B>C>X). Damage to areas TH/TF impaired performance of the DNML at all delays but only affected memory for objects at the longest delay, as measured by a delayed nonmatching-to-sample task (DNMS) (Nemanic et al., 2004). Damage to the PRh impaired performance of the DNMS but not of the DNML. The results present a dissociation in object and place memory for these two cortical regions and suggest a role for each in the cortical circuitry supporting configural/relational memory.

Key words: configural memory; relational memory; discrimination learning; spatial memory; recognition memory; temporal lobe

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Received Oct 29, 2004; revised December 7, 2004; accepted December 31, 2004.

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