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The Journal of Neuroscience, January 4, 2006, 26(1):180-185; doi:10.1523/JNEUROSCI.1073-05.2006

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Behavioral/Systems/Cognitive
Ipsilateral Hand Input to Area 3b Revealed by Converging Hemodynamic and Electrophysiological Analyses in Macaque Monkeys

Michael L. Lipton, ^* Kai-Ming G. Fu, ^* Craig A. Branch, and Charles E. Schroeder

Center for Advanced Brain Imaging and Cognitive Neuroscience Program, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, and Departments of Radiology and Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467

Functional magnetic resonance imaging (fMRI) of the hand representation in primary somatosensory cortex (area 3b) of macaque monkeys revealed an ipsilateral hand input undetected by most previous studies. Ipsilateral responses had a hemodynamic signature indistinguishable from that of contralateral hand responses. We explored the neural mechanisms of the fMRI effects using a second derivative analysis of field potentials [current source density (CSD) analysis] combined with action potential profiles, sampled from area 3b using linear array multielectrodes. In contrast to the predominantly excitatory contralateral response, the colocated ipsilateral response appeared dominated by inhibition, suggesting that ipsilateral inputs may have modulatory effects on contralateral input processing. Our findings confirm bimanual convergence at the earliest stage of cortical somatosensory processing in primates. They also illustrate the value of combined CSD and fMRI analyses in monkeys for defining hidden aspects of sensory function and for investigating the neuronal processes generating fMRI signals.

Key words: somatosensory physiology; ipsilateral response; fMRI; monkey area 3b; cortical feedback; inhibition

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Received March 18, 2005; revised October 28, 2005; accepted October 29, 2005.

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