QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 8, 2006, 26(10):2704-2713; doi:10.1523/JNEUROSCI.3176-05.2006

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Cavina-Pratesi, C. Articles by Goodale, M. A. Search for Related Content PubMed PubMed Citation Articles by Cavina-Pratesi, C. Articles by Goodale, M. A.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Dissociating Arbitrary Stimulus-Response Mapping from Movement Planning during Preparatory Period: Evidence from Event-Related Functional Magnetic Resonance Imaging

Cristiana Cavina-Pratesi,¹ Kenneth F. Valyear,¹ Jody C. Culham,¹ Stefan Köhler,¹ Sukhvinder S. Obhi,² Carlo Alberto Marzi,³ and Melvyn A. Goodale¹

¹Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2, ²Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3G1, and ³Department of Neurological and Vision Sciences, University of Verona, 37134 Verona, Italy

Correspondence should be addressed to Cristiana Cavina-Pratesi, Department of Psychology, University of Durham, Queen’s Campus, Stockton, University Boulevard, Thornaby, Stockton-on-Tees TS17 6BH, UK. Email: cristiana.cavina-pratesi{at}durham.ac.uk

In the present study, we aimed to dissociate the neural correlates of two subprocesses involved in the preparatory period in the context of arbitrary, prelearned stimulus-response (S-R) associations, namely, S-R mapping and movement planning (MP). We teased apart these two subprocesses by comparing three tasks in which the complexity of both S-R mapping and MP were independently manipulated: simple reaction time (SRT) task, go/no-go reaction time (GNGRT) task, and choice reaction time (CRT) task. We found that a more complex S-R mapping, which is the common element differentiating CRT and GNGRT from SRT, was associated with higher brain activation in the left superior parietal lobe (SPL). Conversely, a greater number of planned finger movements, which is the common difference between CRT and both SRT and GNGRT, was associated with higher brain activation in a number of frontal areas, including the left supplementary motor area (SMA), left dorsal premotor cortex (dPM), and left anterior cingulate cortex (ACC). The left-hemisphere dominance for S-R mapping could be related to the fact that arbitrary S-R mapping is often verbally mediated in humans. Overall, these results suggest a clear dissociation in the preparatory-set period between the more abstract role of left SPL in activating the appropriate S-R associations and the more concrete role played by the SMA, dPM, and ACC in preparing the required motor programs.

Key words: fMRI; frontal cortex; superior parietal lobe; motor preparation; S-R mapping; preparatory period; human

---

Received July 29, 2005; revised Jan. 20, 2006; accepted Jan. 22, 2006.

Correspondence should be addressed to Cristiana Cavina-Pratesi, Department of Psychology, University of Durham, Queen’s Campus, Stockton, University Boulevard, Thornaby, Stockton-on-Tees TS17 6BH, UK. Email: cristiana.cavina-pratesi{at}durham.ac.uk

This article has been cited by other articles:

				C. Stelzel, A. Kraft, S. A. Brandt, and T. Schubert Dissociable Neural Effects of Task Order Control and Task Set Maintenance during Dual-task Processing. J. Cogn. Neurosci., April 1, 2008; 20(4): 613 - 628. [Abstract] [Full Text] [PDF]

				T. Hanakawa, M. A. Dimyan, and M. Hallett Motor Planning, Imagery, and Execution in the Distributed Motor Network: A Time-Course Study with Functional MRI Cereb Cortex, March 20, 2008; (2008) bhn036v1. [Abstract] [Full Text] [PDF]

				D. Badre and M. D'Esposito Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex. J. Cogn. Neurosci., December 1, 2007; 19(12): 2082 - 2099. [Abstract] [Full Text] [PDF]

				V. Sluming, J. Brooks, M. Howard, J. J. Downes, and N. Roberts Broca's Area Supports Enhanced Visuospatial Cognition in Orchestral Musicians J. Neurosci., April 4, 2007; 27(14): 3799 - 3806. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help