 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, March 15, 2006, 26(11):2862-2870; doi:10.1523/JNEUROSCI.4048-05.2006
Previous Article | Next Article
Cellular/Molecular
Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling
Monica R. Metea andEric A. Newman Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455
Correspondence should be addressed to Dr. Eric A. Newman, Department of Neuroscience, University of Minnesota, Jackson Hall, 6-145, 321 Church Street Southeast, Minneapolis, MN 55455. Email: ean{at}umn.edu
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function and diagnose pathology, the cellular mechanisms that mediate the response remain unclear. We investigated the contribution of glial cells to neurovascular coupling in the acutely isolated mammalian retina. We found that light stimulation and glial cell stimulation can both evoke dilation or constriction of arterioles. Light-evoked and glial-evoked vasodilations were blocked by inhibitors of cytochrome P450 epoxygenase, the synthetic enzyme for epoxyeicosatrienoic acids. Vasoconstrictions, in contrast, were blocked by an inhibitor of
-hydroxylase, which synthesizes 20-hydroxyeicosatetraenoic acid. Nitric oxide influenced whether vasodilations or vasoconstrictions were produced in response to light and glial stimulation. Light-evoked vasoactivity was blocked when neuron-to-glia signaling was interrupted by a purinergic antagonist. These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components.
Key words: blood flow; glia; arachidonic acid metabolites; calcium; retina; ATP
Received Sept. 23, 2005; revised Feb. 1, 2006; accepted Feb. 1, 2006.
Correspondence should be addressed to Dr. Eric A. Newman, Department of Neuroscience, University of Minnesota, Jackson Hall, 6-145, 321 Church Street Southeast, Minneapolis, MN 55455. Email: ean{at}umn.edu
This article has been cited by other articles:
A. M. Guo, J. Sheng, G. M. Scicli, A. S. Arbab, N. L. Lehman, P. A. Edwards, J. R. Falck, R. J. Roman, and A. G. Scicli
Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo
J. Pharmacol. Exp. Ther., October 1, 2008; 327(1): 10 - 19.
[Abstract] [Full Text] [PDF]
E. Sykova and C. Nicholson
Diffusion in Brain Extracellular Space
Physiol Rev, October 1, 2008; 88(4): 1277 - 1340.
[Abstract] [Full Text] [PDF]
K. Holmgaard, C. Aalkjaer, J. D. C. Lambert, and T. Bek
N-Methyl-D-Aspartic Acid Causes Relaxation of Porcine Retinal Arterioles through an Adenosine Receptor-Dependent Mechanism
Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4590 - 4594.
[Abstract] [Full Text] [PDF]
T. M. Schmidt, K. Taniguchi, and P. Kofuji
Intrinsic and Extrinsic Light Responses in Melanopsin-Expressing Ganglion Cells During Mouse Development
J Neurophysiol, July 1, 2008; 100(1): 371 - 384.
[Abstract] [Full Text] [PDF]
J. Schummers, H. Yu, and M. Sur
Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex
Science, June 20, 2008; 320(5883): 1638 - 1643.
[Abstract] [Full Text] [PDF]
V. M. Blanco, J. E. Stern, and J. A. Filosa
Tone-dependent vascular responses to astrocyte-derived signals
Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2855 - H2863.
[Abstract] [Full Text] [PDF]
K. E. Kotliar, B. Mucke, W. Vilser, R. Schilling, and I. M. Lanzl
Effect of Aging on Retinal Artery Blood Column Diameter Measured along the Vessel Axis
Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2094 - 2102.
[Abstract] [Full Text] [PDF]
Z. Yuan, T. W. Hein, R. H. Rosa Jr, and L. Kuo
Sildenafil (Viagra) Evokes Retinal Arteriolar Dilation: Dual Pathways via NOS Activation and Phosphodiesterase Inhibition
Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 720 - 725.
[Abstract] [Full Text] [PDF]
J. C. Saez
Astrocytes as connexin-dependent signaling cells for local blood flow regulation
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H586 - H587.
[Full Text] [PDF]
A. Li, Q. Xi, E. S. Umstot, L. Bellner, M. L. Schwartzman, J. H. Jaggar, and C. W. Leffler
Astrocyte-Derived CO Is a Diffusible Messenger That Mediates Glutamate-Induced Cerebral Arteriolar Dilation by Activating Smooth Muscle Cell KCa Channels
Circ. Res., February 1, 2008; 102(2): 234 - 241.
[Abstract] [Full Text] [PDF]
M. R. Metea and E. A. Newman
Signalling within the neurovascular unit in the mammalian retina
Exp Physiol, July 1, 2007; 92(4): 635 - 640.
[Abstract] [Full Text] [PDF]
J. A. Filosa and V. M. Blanco
Neurovascular coupling in the mammalian brain
Exp Physiol, July 1, 2007; 92(4): 641 - 646.
[Abstract] [Full Text] [PDF]
E. Chaigneau, P. Tiret, J. Lecoq, M. Ducros, T. Knopfel, and S. Charpak
The Relationship between Blood Flow and Neuronal Activity in the Rodent Olfactory Bulb
J. Neurosci., June 13, 2007; 27(24): 6452 - 6460.
[Abstract] [Full Text] [PDF]
J. Chuquet, L. Hollender, and E. A. Nimchinsky
High-Resolution In Vivo Imaging of the Neurovascular Unit during Spreading Depression
J. Neurosci., April 11, 2007; 27(15): 4036 - 4044.
[Abstract] [Full Text] [PDF]
A. J. Strong, P. J. Anderson, H. R. Watts, D. J. Virley, A. Lloyd, E. A. Irving, T. Nagafuji, M. Ninomiya, H. Nakamura, A. K. Dunn, et al.
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
Brain, April 1, 2007; 130(4): 995 - 1008.
[Abstract] [Full Text] [PDF]
G. Burnstock
Physiology and Pathophysiology of Purinergic Neurotransmission
Physiol Rev, April 1, 2007; 87(2): 659 - 797.
[Abstract] [Full Text] [PDF]
M. R. Metea, P. Kofuji, and E. A. Newman
Neurovascular Coupling Is Not Mediated by Potassium Siphoning from Glial Cells
J. Neurosci., March 7, 2007; 27(10): 2468 - 2471.
[Abstract] [Full Text] [PDF]
S. V. Straub, A. D. Bonev, M. K. Wilkerson, and M. T. Nelson
Dynamic Inositol Trisphosphate-mediated Calcium Signals within Astrocytic Endfeet Underlie Vasodilation of Cerebral Arterioles
J. Gen. Physiol., December 1, 2006; 128(6): 659 - 669.
[Abstract] [Full Text] [PDF]
M. Domercq, L. Brambilla, E. Pilati, J. Marchaland, A. Volterra, and P. Bezzi
P2Y1 Receptor-evoked Glutamate Exocytosis from Astrocytes: CONTROL BY TUMOR NECROSIS FACTOR-{alpha} AND PROSTAGLANDINS
J. Biol. Chem., October 13, 2006; 281(41): 30684 - 30696.
[Abstract] [Full Text] [PDF]
P. G. Haydon and G. Carmignoto
Astrocyte control of synaptic transmission and neurovascular coupling.
Physiol Rev, July 1, 2006; 86(3): 1009 - 1031.
[Abstract] [Full Text] [PDF]
A. Rancillac, J. Rossier, M. Guille, X.-K. Tong, H. Geoffroy, C. Amatore, S. Arbault, E. Hamel, and B. Cauli
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
J. Neurosci., June 28, 2006; 26(26): 6997 - 7006.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|