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The Journal of Neuroscience, March 22, 2006, 26(12):3229-3244; doi:10.1523/JNEUROSCI.4333-05.2006
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Cellular/Molecular
Dopaminergic Regulation of Neuronal Excitability through Modulation of Ih in Layer V Entorhinal Cortex
J. Amiel Rosenkranz andDaniel Johnston Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712
Correspondence should be addressed to J. Amiel Rosenkranz, Center for Learning and Memory, 1 University Station, C7000, University of Texas at Austin, Austin, TX 78712. Email: amiel{at}mail.clm.utexas.edu
The entorhinal cortex (EC) is a significant component of the systems that underlie certain forms of memory formation and recall. Evidence has been emerging that the dopaminergic system in the EC facilitates these and other functions of the EC. The effects of dopamine (DA) on membrane properties and excitability of EC neurons, however, are not known. We used in vitro whole-cell patch-clamp recordings from layer V pyramidal neuronal somata and dendrites of the adult rat lateral EC to investigate the effects of DA on the excitability of these neurons. We found that brief application of DA caused a reduction in the excitability of layer V EC pyramidal neurons. This effect was attributable to voltage-dependent modification of membrane properties that can best be explained by an increase in a hyperpolarization-activated conductance. Furthermore, the effects of DA were blocked by pharmacological blockade of h-channels, but not by any of a number of other ion channels. These actions were produced by a D1 receptor-mediated increase of cAMP but were independent of protein kinase A. A portion of the actions of DA can be attributed to effects in the apical dendrites. The data suggest that DA can directly influence the membrane properties of layer V EC pyramidal neurons by modulation of h-channels. These actions may underlie some of the effects of DA on memory formation.
Key words: dopamine; entorhinal cortex; whole cell; patch clamp; rat; hyperpolarization-activated current; voltage sag
Received Oct. 11, 2005; revised Jan. 20, 2006; accepted Feb. 13, 2006.
Correspondence should be addressed to J. Amiel Rosenkranz, Center for Learning and Memory, 1 University Station, C7000, University of Texas at Austin, Austin, TX 78712. Email: amiel{at}mail.clm.utexas.edu
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