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The Journal of Neuroscience, March 22, 2006, 26(12):3281-3291; doi:10.1523/JNEUROSCI.4955-05.2006

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Cellular/Molecular
Retinoic Acid Receptor-Dependent Survival of Olfactory Sensory Neurons in Postnatal and Adult Mice

Maria Hägglund,¹ Anna Berghard,¹ Jörg Strotmann,² and Staffan Bohm¹

¹Department of Molecular Biology, Umeå University, SE901 87 Umeå, Sweden, and ²Institute of Physiology, University of Hohenheim, D-70593 Stuttgart, Germany

Correspondence should be addressed to Staffan Bohm, Department of Molecular Biology, Umeå University, Umeå, SE901 87 Sweden. Email: staffan.bohm{at}molbiol.umu.se

To address the hypothesis that retinoids produced by synthesizing enzymes present in the primary olfactory system influence the mouse olfactory sensory map, we expressed a dominant-negative retinoic acid receptor selectively in olfactory sensory neurons. We show that neurons deficient in nuclear retinoid signaling are responsive to odors and form correct odorant receptor-specific axonal projections to target neurons in the olfactory bulb of the brain. Subsequent to the formation of the map, the neurons die prematurely by retrograde-driven caspase-3 activation, which resembles the previously described mechanism of neural death after olfactory bulb ablation. This neurodegenerative event is initiated the second postnatal week and occurs in the adult animal without a compensatory increase of progenitor cell proliferation. In addition, we find that nuclear retinoid signaling is required for the expression of a retinoic acid-degrading enzyme, Cyp26B1, in a small fraction of mature neurons. Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation.

Key words: apoptosis; neuron; olfactory; RAR; postnatal; retinoic acid

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Received Nov. 21, 2005; revised Feb. 7, 2006; accepted Feb. 7, 2006.

Correspondence should be addressed to Staffan Bohm, Department of Molecular Biology, Umeå University, Umeå, SE901 87 Sweden. Email: staffan.bohm{at}molbiol.umu.se

This article has been cited by other articles:

				M. A. Asson-Batres, W. B. Smith, and G. Clark Retinoic Acid Is Present in the Postnatal Rat Olfactory Organ and Persists in Vitamin A-Depleted Neural Tissue J. Nutr., June 1, 2009; 139(6): 1067 - 1072. [Abstract] [Full Text] [PDF]

				A. S. Borders, M. A. Hersh, M. L. Getchell, N. van Rooijen, D. A. Cohen, A. J. Stromberg, and T. V. Getchell Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium Physiol Genomics, November 14, 2007; 31(3): 531 - 543. [Abstract] [Full Text] [PDF]

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