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The Journal of Neuroscience, March 29, 2006, 26(13):3584-3588; doi:10.1523/JNEUROSCI.5146-05.2006

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Brief Communications
Different Neural Substrates Mediate Cocaine Seeking after Abstinence versus Extinction Training: A Critical Role for the Dorsolateral Caudate–Putamen

Rita A. Fuchs,² R. Kyle Branham,¹ and Ronald E. See¹

¹Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, and ²Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270

Correspondence should be addressed to Ronald E. See, Medical University of South Carolina, Department of Neurosciences, 173 Ashley Avenue, Suite 416B, Charleston, SC 29425. Email: seere{at}musc.edu

Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse. However, relapse typically occurs after abstinence rather than explicit extinction training. We show that inactivation of the dorsolateral caudate–putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence. This suggests that there is limited overlap in the substrates of cocaine seeking after abstinence versus extinction, and that habit learning exerts greater control over drug seeking than regions implicated in stimulus–reward associations.

Key words: dorsal striatum; caudate-putamen; cocaine; self-administration; reinstatement; extinction; abstinence

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Received Dec. 2, 2005; revised Feb. 7, 2006; accepted Feb. 28, 2006.

Correspondence should be addressed to Ronald E. See, Medical University of South Carolina, Department of Neurosciences, 173 Ashley Avenue, Suite 416B, Charleston, SC 29425. Email: seere{at}musc.edu

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